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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
16 January 2008 - 14 May 2008
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: The study has been performed according to OECD and EC guidelines and according to GLP principles.

Data source

Reference Type:
study report
Report date:

Materials and methods

Test guidelineopen allclose all
according to guideline
OECD Guideline 105 (Water Solubility)
according to guideline
EU Method A.6 (Water Solubility)
Principles of method if other than guideline:
During the water solubility test, the maximum difference between the measurements of the last two sampling points was more 20% while it should be within 15%.
Evaluation: The test substance is a fine powder and it proved difficult to remove undissolved matter through centrifugation. This was the best possible result to achieve.
The study integrity was not adversely affected by the deviations.
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Details on test material:
- Name of test material (as cited in study report): S-500
- Physical state: yellow powder
- Lot/batch No.: MF1456-2345
- Expiration date of the lot/batch: 18 August 2011
- Storage condition of test material: At room temperature in the dark
- Stability under storage conditions: Stable

Results and discussion

Water solubility
Water solubility:
0.001 g/L
19.6 °C
Details on results:
The maximum difference (MD) of the concentrations determined in the 24, 48 and 72 hour test samples was > 15%. The spread in data can be explained by the nature of the test substance, which is a fine powder that was finely dispersed in the water phase and therefore difficult to remove by centrifugation. As the maximum difference > 15%, then according to the guidelines, the water solubility of the test substance was given as the mean value of the 48- and 72-hour measurements.

Applicant's summary and conclusion

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The flask method was chosen for the determination of the water solubility of S-500. The water solubility of the test substance at 19.6°C ± 0.5°C was 0.71 x 10^-3 g/l. The pH of the aqueous samples after 72 hours stirring was 5.37.