Registration Dossier
Registration Dossier
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EC number: 206-575-6 | CAS number: 355-04-4
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation in aquatic species: fish
- Type of information:
- read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Justification for type of information:
- It is well established that saturated perfluorocarbons form a class of chemicals with very similar properties.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 984
- Report date:
- 1984
Materials and methods
Test guideline
- Guideline:
- OECD Guideline 305 A (Bioaccumulation: Sequential Static Fish Test)
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Perfluoroperhydrophenanthrene
- EC Number:
- 400-470-0
- EC Name:
- Perfluoroperhydrophenanthrene
- Cas Number:
- 306-91-2
- Molecular formula:
- C14F24
- IUPAC Name:
- 1,1,2,2,3,3,4,4,4a,4b,5,5,6,6,7,7,8,8,8a,9,9,10,10,10a-Tetracosafluorophenanthrene
- Test material form:
- liquid
Constituent 1
- Radiolabelling:
- no
Test solutions
- Vehicle:
- yes
- Remarks:
- HCO-20 (x10) ad F-142D Megafac (x20)
Test organisms
- Test organisms (species):
- Cyprinus carpio
- Details on test organisms:
- Sterilised in static solution of chlorotetracycline hydrochloride (10 mg/l) for 24 hours, acclimatised for 14 days.
Average: body weight 22.4g; length 9.7 cm, lipid content 4.2%.
Study design
- Route of exposure:
- aqueous
- Justification for method:
- other: Done to support entry into Japanese market at that time
- Test type:
- flow-through
- Water / sediment media type:
- natural water
- Total exposure / uptake duration:
- ca. 8 wk
Test conditions
- Test temperature:
- 23 to 27°C
- Dissolved oxygen:
- 3.0 to 5.4 mg/l
- Nominal and measured concentrations:
- Level 1: nominal 1.0 mg/l, measured at 0.807, 0.858, 0.846, 0.839
Level 2: nominal 0.1 mg/l; measured at 0.0790, 0.0832, 0.0867, 0.0889 - Reference substance (positive control):
- not specified
Results and discussion
Bioaccumulation factoropen allclose all
- Key result
- Conc. / dose:
- > 0.8 - < 0.9 mg/L
- Temp.:
- >= 23 - <= 27 °C
- Type:
- BCF
- Value:
- >= 0.2 - <= 4.7 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 8 wk
- Conc. / dose:
- > 0.08 - < 0.09 mg/L
- Temp.:
- >= 23 - <= 27 °C
- Type:
- BCF
- Value:
- >= 7.3 - <= 30 dimensionless
- Basis:
- whole body w.w.
- Time of plateau:
- 8 wk
Applicant's summary and conclusion
- Conclusions:
- The material exhibits minimal bioconcentration.
- Executive summary:
The material exhibits minimal bioconcentration.
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