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Long-term toxicity to aquatic invertebrates

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Description of key information

The long-term toxicity of ATBC to daphnids was assessed in a test according to OECD 211:
EC50 (21 d) > 1.11 mg/L (reproduction rate)
NOEC (21 d) ≥ 1.11 mg/L (reproduction rate and survival of the adult test animals)
LOEC (21 d) ≥ 1.11 mg/L (reproduction rate and survival of the adult test animals) [Read-across data from tributyl-O-acetylcitrate (CAS 77-90-7)]

Key value for chemical safety assessment

EC10, LC10 or NOEC for freshwater invertebrates:
1.11 mg/L

Additional information

No experimental data is available to assess the chronic toxicity of tris(2-ethylhexyl) 2 -(acetyloxy)propane-1,2,3-tricarboxylate (CAS 144 -15 -0) to aquatic invertebrates. Therefore, the so-called read-across approach to the substance 1,2,3-Propanetricarboxylic acid, 2-(acetyloxy)-, 1,2,3-tributyl ester (ATBC) is intended. For further details and justification of this procedure please refer to the separate Read-Across Statement. The substance was investigated on the survival and reproduction rate of Daphnia magna was determined during an exposure period of 21 days according to OECD 211 and EU method C20 without GLP compliance [2010]. The 21-day NOEC and LOEC values were determined to be ≥ 1.11 mg test item/L for the reproduction rate and ≥ 1.11 mg test item/L for the survival of the adult test animals, respectively. The EC50 for the reproduction rate was > 1.11 mg test item/L (effect value based on analytical monitoring - TWA). It can be assumed that the same applies to tris(2-ethylhexyl) 2-(acetyloxy)propane-1,2,3-tricarboxylate (CAS 144 -15 -0) as it is a near analogue to the test substance acetyl tributyl citrate (ATBC).