Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-617-0 | CAS number: 144-15-0
Grading of skin reaction (as stipulated by OECD 404)
Maximum possible (both formations): 4
The potential toxicity of tris(2-ethylhexyl) 2-(acetyloxy)propane-1,2,3-tricarboxylate (ATEHC) was assessed in an acute dermal irritation/corrosion test on 3 male albino rabbits according to OECD 404 and EU method B.4 and in compliance with GLP (2000). To assess dermal reactions to the test substance, one of these animals was treated in advance. The test item was applied to gauze patches which were then applied to the skin. Three test patches were applied concurrently to the animal. The first patch was removed after 3 min, the second and third patch were removed after 1 h and 4 h, respectively. Since no skin reactions were observed, in the two further animals, 0.5 ml of the test substance was applied on the right side of the dorsal clipped region, the untreated left side served as control. Exposure duration was 4 h. Both sides were examined at 1, 24, 48 and 72 h after the end of exposure and the following results were obtained: Very slight erythema was observed in one animal (no. 3) 1 h after the 4-hour exposure. This finding was still apparent 24 h after exposure, but fully reversible within 48h. Subsequently, no findings were observed. Further no other toxic effects were observed.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
Welcome to the ECHA website. This site is not fully supported in Internet Explorer 7 (and earlier versions). Please upgrade your Internet Explorer to a newer version.
Close Do not show this message again