Registration Dossier
Registration Dossier
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EC number: 200-471-4 | CAS number: 60-34-4
Carcinogenicity
Administrative data
Description of key information
Key value for chemical safety assessment
Justification for classification or non-classification
Additional information
The carcinogenicity of methylhydrazine and other hydrazines has been extensively investigated. For an overview see ACGIH 2001. The conclusion is that methyl hydrazine, like hydrazine, is carcinogenic in rodents when administered at overtly toxic doses (nasal epithelial irritation) doses for lifetime. The main target organs following inhalation are liver, lungs and the nasal epithelium.
The classification R45 / Cancer Cat 1B is suggested for methylhydrazine, based on:
- Increased incidence of lung adenomas and liver adenoma / carcinoma in mice following inhalative exposure for one year (Kinkread et al., 1985, Air Force Aerospace Medical Research Lab).
- Increase incidence of malignant histiocytomas and tumours of the cecum in hamster following lifetime expore of 0.01% via the drinking water (Toth and Shimizu, Cancer Research, 33, pages 2744 - 2653, 1973)
As human relevance of the neoplastic effects in animals cannot be excluded, the proposed classification is warranted.
Legal classification of other hydrazines also includes R45 / Cancer Cat 1B (see Annex VI of REACh).
The Dutch Expert Committee on Occupational Standards also suggested that Methylhydrazine should be considered as carcinogenic to humans.
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