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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

Methyl hydrazine is generally inactive in tests designed to measure mutagenic activity (ACGIH 2001). There are indications for a weak positive response in some tests.

in vivo tests:

Dominant Lethal Assay (mice): negative       (Matheson et al., 1978, [Mutation Research, 53:93])

MNT (dogs): negative                                (Beng et al., 1980, [Environ. Mutagen., 2:312])

Host mediated assay (mice): negative           (von Wright et al., 1978, [Mutation Research, 54:167])

Alkaline elution/rat hepatocyte assay: negative (Sina et al., 1983, [Mutation Research, 113, 357 -391])

Alkaline elution/rat hepatocyte assay: positive (Parodi et al., 1980, [Proc. Am. Assoc. Cancer Res., 21, 99])


Endpoint Conclusion:

Justification for classification or non-classification