3,3,5-trimethylcyclohexan-1-one

Skin irritation / corrosion

Administrative data

Endpoint:

skin irritation: in vivo

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

abstract

Justification for type of information:

Data is from abstract of NTIS study report

Data source

Reference

Reference Type:

secondary source

Title:

Acute dermal application - albino rabbits

Author:

National Technical Information Service

Year:

1964

Bibliographic source:

National Technical Information Service, OTS0206267, June 17, 1964

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

other: As mentioned below

Principles of method if other than guideline:

The acute dermal irritation test for the chemical 3,3,5-trimethylcyclohexan-1-one was conducted in albino rabbits for eight-days.

GLP compliance:

not specified

Test material

Test material information

Constituent 1

Reference substance name:

3,3,5-trimethylcyclohexan-1-one

EC Number:

212-855-9

EC Name:

3,3,5-trimethylcyclohexan-1-one

Cas Number:

873-94-9

Molecular formula:

C9H16O

IUPAC Name:

3,3,5-trimethylcyclohexan-1-one

Test material form:

liquid

Details on test material:

- Name of test material :3,3,5-trimethylcyclohexan-1-one
- IUPAC name: 3,3,5-Trimethylcyclohexanone
- Molecular formula :C9H16O
- Molecular weight :140.224
- Smiles notation :C1(C[C@@H](CC(C1)=O)C)(C)C
- InChl :1S/C9H16O/c1-7-4-8(10)6-9(2,3)5-7/h7H,4-6H2,1-3H3
- Substance type: Organic
- Physical state: liquid

Specific details on test material used for the study:

- Name of test material :3,3,5-trimethylcyclohexan-1-one
- Molecular formula :C9H16O
- Molecular weight :140.224
- Smiles notation :C1(C[C@@H](CC(C1)=O)C)(C)C
- InChl :1S/C9H16O/c1-7-4-8(10)6-9(2,3)5-7/h7H,4-6H2,1-3H3
- Substance type: Organic
- Physical state: liquid

Test animals

Species:

rabbit

Strain:

other: Albino

Details on test animals or test system and environmental conditions:

No data

Test system

Type of coverage:

not specified

Preparation of test site:

not specified

Vehicle:

not specified

Controls:

not specified

Amount / concentration applied:

200,794 and 3160 mg/kg (other doses not specified)

Duration of treatment / exposure:

No data

Observation period:

8 days

Number of animals:

No data

Details on study design:

No data

Results and discussion

In vivo

Results

Irritation parameter:

erythema score

Basis:

mean

Time point:

24 h

Reversibility:

not specified

Remarks on result:

other: slight erythema at all levels at 24 hours only followed by slight desquamation in one or two animals at each of the three higher levels.

Remarks:

other details not available

Other effects:

Transient diarrhea for two days in four animals (one at 200 and 794 levels and two at 3160 mg/kg level).

Applicant's summary and conclusion

Interpretation of results:

Category 2 (irritant) based on GHS criteria

Conclusions:

Acute dermal irritation test of substance 3,3,5-trimethylcyclohexan-1-one in rabbits for 8 days induced slight erythema for all the tested concentration at 24 hrs.

Executive summary:

Acute dermal irritation test was conducted for the test substance 3,3,5-trimethylcyclohexan-1-one in rabbits for 8 days. Rabbits were exposed to gradually increasing concentration of the test substance.Slight erythema was observed at all levels at 24 hours only followed by slight desquamation in one or two animals at each of the three higher levels. Also, transient diarrhea for two days in four animals (one at 200 and 794 levels and two at 3160 mg/kg level) were noticed.

Based on the above study, test chemical 3,3,5-trimethylcyclohexan-1-one can be considered to be irritating to skin and can be classified under the category “Category 2”as per CLP regulation.