Registration Dossier
Registration Dossier
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EC number: 629-718-8 | CAS number: 127946-77-4
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Given the precision required (the solubility is determined as a range), no sufficient human error is expected which could lead to a non reliable result.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Report date:
- 2010
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: European Pharmacopoeia 5.0 : Solubility
- Principles of method if other than guideline:
- 1-Tared a dried volumetric flask at a fixed temperature of 20°C.
2-Fill in the flask with 100mg of the substance
3-Add 0.1ml of water and check if the sustance is solubilized (very soluble): if not go to step 4)
4-Add 0.9mL of water and check if the sustance is solubilized (easily soluble): if not go to step 5)
5-Add 2mL of water and check if the sustance is solubilized (soluble): if not go to step 6)
6-Add 7mL of water and check if the sustance is solubilized (moderately soluble): if not go to step 7)
7-Tared a dried volumetric flask at a fixed temperature of 20°C.
Fill in the flask with 10mg of the substance, add 10mL of water and check if the sustance is solubilized (slightly soluble): if not go to step 8)
8-Tared a dried volumetric flask at a fixed temperature of 20°C.
Fill in the flask with 1mg of the substance, add 10mL of water and check if the sustance is solubilized (very poorly soluble). - GLP compliance:
- yes
- Type of method:
- other: European Pharmacopoeia 5.0 : Solubility
Test material
- Reference substance name:
- 1-Amino-1-cyclopropanecarbonitrile hydrochloride
- EC Number:
- 629-718-8
- Cas Number:
- 127946-77-4
- Molecular formula:
- C4H7N2Cl
- IUPAC Name:
- 1-Amino-1-cyclopropanecarbonitrile hydrochloride
- Reference substance name:
- 1-aminocyclopropane-1-carbonitrile hydrochloride
- IUPAC Name:
- 1-aminocyclopropane-1-carbonitrile hydrochloride
Constituent 1
Constituent 2
Results and discussion
Water solubility
- Water solubility:
- >= 100 - <= 1 000 mg/L
- Temp.:
- 20 °C
- pH:
- ca. 2.6
- Details on results:
- 100mg of the substance is soluble in 10ml of water.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): moderately soluble (100-1000 mg/L)
Solubility at 20°C in water is 100 to 1000mg/L =>The substance is moderately soluble according to European Pharmacopoeia 5.0
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