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EC number: 225-924-3 | CAS number: 5153-24-2
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Endpoint summary
Administrative data
Description of key information
Based on the OECD guideline 404 and 405 studies, zirconium di(acetate) oxide is not considered irritating to skin, but causes irreversible effects to the eyes.
Key value for chemical safety assessment
Skin irritation / corrosion
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Additional information
In a non-GLP OECD guideline 404 study with 3 rabbits (RCC AG, 1986a), application of 0.5 mL of the test substance for 4 hours under occlusive conditions produced no effects at 1, 24, 48 and 72 hours after removal (erythema score: 0, edema score: 0). In the area of application no staining of the treated skin by pigment or coloring of the test article was observed. No destructions or irreversible alterations of the treated skin were observed. No corrosive effect was evident on the skin. Based on these results, the substance is considered to be not irritating to skin.
In a non-GLP OECD guideline 405 study with 3 rabbits (RCC AG, 1986b), single instillation of 0.1 mL of the test substance in the conjunctival sac produced irritating effects. The mean 24 + 48 + 72 hours scores were 2.0 for cornea, 0.6 for iris, 1.7 for conjunctival redness and 1.9 for chemosis. After 21 days, the substance still produced corneal opacity (whole area, from slight to severe) and visible vascularization in all 3 animals (mean cornea score of 1.3). Slight redness of conjunctiva (score 1) was still observed after 21 days in one animal. In the area of application no staining of the cornea and conjunctivae by pigment or coloring of the test article was observed. Based on irreversibility of the effects on the cornea after 21 days post-application, the substance is concluded to produce irreversible effects to the eyes.
Effects on eye irritation: corrosive
Justification for classification or non-classification
Based on the mean erythema and edema scores of 0 in the OECD guideline 404 study with rabbits, classification of zirconium di(acetate) oxide for skin irritation is not warranted in accordance with with EU Directive 67/548 and EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
Based on the irreversible effects on the cornea within the 21 days observation period in the OECD guideline 405 study, zicronium di(acetate) oxide needs to be classified as: Irreversible Effects on the Eye (Category 1), H318 (Causes serious eye damage) according to EU Classification, Labeling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008. This classification translates into classification according to EU Directive 67/548/EEC as Xi, R41 (risk of serious damage to eyes).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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