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EC number: 251-807-1
CAS number: 34041-09-3
Selected endpoints for the human health hazard assessment are addressed by read-across, using a combination of data on the metal cation and the organic acid anion. This way forward is acceptable, since metal carboxylates are shown to dissociate to the organic anion and the metal cation upon dissolution in aqueous media. No indications of complexation or masking of the metal ion through the organic acid were apparent during the water solubility and dissociation tests (please refer to the water solubility and dissociation in sections 4.8 and 4.21 of IUCLID). Once the individual transformation products of the metal carboxylate become bioavailable (i.e. in the acidic environment in the gastric passage or after phagocytosis by pulmonary macrophages), the “overall” toxicity of the dissociated metal carboxylate can be described by a combination of the toxicity of these transformation products, i.e. the metal cation and carboxylate anion according to an additivity approach.
2-ethylhexanoic, molybdenum salt is the molybdenum metal salt of 2-ethylhexanoic acid, which readily dissociates to the corresponding molybdenum and 2-ethylhexanoate ions. These ions are considered to represent the overall toxicity of 2-ethylhexanoic, molybdenum salt in a manner proportionate to the free acid and the metal (represented by one of its readily soluble salts).
A detailed justification for the read-across approach is added as a separate document in section 13 of IUCLID.
No skin sensitisation study with 2-ethylhexanoic acid, molybdenum salt is available, thus the skin sensitisation potential will be addressed with existing data on the dissociation products as detailed in the table below. Further details on the skin sensitisation potential of the individual constituents within the framework of regulation (EC) 1907/2006 are given below.
Table: Summary of skin sensitisation data of 2-ethylhexanoic acid, molybdenum salt and the individual constituents.
2-ethylhexanoic acid, molybdenum salt(CAS# 34041-09-3)
2-ethylhexanoic acid, molybdenum salt is not expected to show signs of dermal sensitisation, since the two constituents molybdate and 2-ethylhexanoic acid have not shown any skin sensitisation potential in experimental testing. Thus, 2-ethylhexanoic acid, molybdenum salt is not to be classified according to regulation (EC) 1272/2008 as skin sensitising. Further testing is not required. For further information on the toxicity of the individual constituents, please refer to the relevant sections in the IUCLID and CSR.
According to the CLP regulation the hazard identification and subsequently a proposal for classification as “Respiratory sensitiser” will normally be based on human experience. In this context, hypersensitivity is normally seen as asthma, but other hypersensitivity reactions such as rhinitis/conjunctivitis and alveolitis are also considered. The condition will have the clinical character of an allergic reaction. However, immunological mechanisms do not have to be demonstrated.
The evidence could be:
2-ethylhexanoic acid, molybdenum salt is not expected to show a respiratory sensitising potential.
2-ethylhexanoic acid, molybdenum salt is not expected to show signs of dermal sensitisation, since the two constituents molybdate and 2-ethylhexanoic acid have not shown any skin sensitisation potential in experimental testing. Thus, 2-ethylhexanoic acid, molybdenum salt is not to be classified according to regulation (EC) 1272/2008 as skin sensitising.
In long-time industrial experience in the production and handling of substance 2-ethylhexanoic acid, molybdenum salt, no cases of respiratory hypersensitivity have been observed. Classification as respiratory sensitiser is not applicable.
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