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Toxicological information

Eye irritation

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Administrative data

Endpoint:
eye irritation: in vivo
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Study was conducted pre-GLP and pre-guideline, so details in the report are lacking. However, the study was conducted at a highly reputable laboratory, and was done to the state of the art at the time.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1960

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
Deviations:
not specified
Principles of method if other than guideline:
The study was conducted prior to OECD guidelines, but it follows the general layout of OECD 405.
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Butyronitrile
EC Number:
203-700-6
EC Name:
Butyronitrile
Cas Number:
109-74-0
Molecular formula:
C4H7N
IUPAC Name:
butanenitrile

Test animals / tissue source

Species:
rabbit
Strain:
not specified
Details on test animals or tissues and environmental conditions:
None given

Test system

Vehicle:
unchanged (no vehicle)
Controls:
no
Amount / concentration applied:
1 drop
Duration of treatment / exposure:
14 days
Observation period (in vivo):
14 days
Number of animals or in vitro replicates:
1
Details on study design:
One drop of test article was applied to the eyes of a single rabbit followed by a 14-day observation period

Results and discussion

In vivo

Results
Irritation parameter:
other:
Time point:
other: 24 hours
Score:
> 0 - < 0
Reversibility:
not specified
Remarks on result:
other: No score was given but as TCC demands a value, dummy numbers were used.
Irritant / corrosive response data:
Eyes were held closed briefly. Slight erythema of conjunctiva. Normal at 1 hr and 24 hours, although there was slight staining of nictitating membrane with fluorescein. Normal at 14 days.

Applicant's summary and conclusion

Interpretation of results:
slightly irritating
Remarks:
Migrated information Criteria used for interpretation of results: expert judgment
Conclusions:
The test article was minimally irritating.
Executive summary:

The test article was minimally irritating. Note that this study only used a qualitative grade. Numerical values were added as TCC required them, but such grades were not provided in the study.