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Description of key information

The substance calcium iodate is classified as irritating to skin and eye.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records
Reference
Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Qualifier:
according to
Guideline:
other:
Principles of method if other than guideline:
Data is from Dictionary of Substances and their effects (DOSE) database
GLP compliance:
not specified
Species:
human
Strain:
not specified
Type of coverage:
not specified
Preparation of test site:
not specified
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
no data
Observation period:
no data
Number of animals:
no data
Irritation parameter:
overall irritation score
Basis:
mean
Remarks on result:
other: Irritating to humans
Interpretation of results:
irritating
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Potassium iodate is found to be irritant to skin and mucous membranes of humans
Executive summary:

Potassium iodate is found to be irritant to skin and mucous membranes of humans

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Eye irritation

Link to relevant study records
Reference
Endpoint:
eye irritation: in vivo
Type of information:
(Q)SAR
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Justification for type of information:
QSAR prediction: migrated from IUCLID 5.6
Qualifier:
according to
Guideline:
OECD Guideline 405 (Acute Eye Irritation / Corrosion)
GLP compliance:
no
Species:
other: human; rabbit
Strain:
other: not applicable
Vehicle:
not specified
Controls:
not specified
Duration of treatment / exposure:
no data
Observation period (in vivo):
no data
Number of animals or in vitro replicates:
no data
Irritation parameter:
overall irritation score
Basis:
mean
Reversibility:
not specified
Remarks on result:
other: Calcium iodate can produce retinal toxicity that damages RPE and photoreceptor cells.

Estimation method: Taking highest mode value from the 5 nearest neighbours


("a" and "b" )

Domain logical expression index: "a"

Parametric boundary:The target chemical should have a value of log Kow which is >= -7.18

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is <= -7.18

Interpretation of results:
Category 2A (irritating to eyes)
Remarks:
Migrated information Criteria used for interpretation of results: EU
Conclusions:
Calcium iodate can produce retinal toxicity that damages RPE and photoreceptor cells. The recovery of retinal function depends on the amount of chemical absorption, the regeneration of RPE, and the recovery function of photoreceptor cells.
Executive summary:

Calcium iodate can produce retinal toxicity that damages RPE and photoreceptor cells. The recovery of retinal function depends on the amount of chemical absorption, the regeneration of RPE, and the recovery function of photoreceptor cells. The substance is classified in eye irritation Category 2A as per the CLP criteria.

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion
Endpoint conclusion:
no study available

Additional information

Skin irritation:

Based on studies of read across chemicals reviewed for skin irritation from reliable sources having Klimisch rating 2 and 4.

The summary of the results are presented below

 

Sr. No

End point

effect

Species

Remark

1

Overall irritation score

irritating

humans

Data is from DOSE for CAS NO 7758-05-6

2

Overall irritation score

moderately irritating

rabbit

Data is from publication CAS NO 7681-82-5

 

Thus by applying weight of evidence approach to the studies summarized in the above table it can be concluded that the substance is irritating to the skin of human and rabbit. Thus Calcium iodate was considered to be skin irritant as the criteria of CLP regulation

Eye irritation:

Based on studies of target substance calcium iodate and read across reviewed for eye irritation from reliable sources having Klimisch rating 2 and 4 considering weight of evidence approach

 

The summary of the results are presented below

 

Sr. No

End point

effect

Species

Remark

1

Other

retinal toxicity that damages RPE and photoreceptor cells

 

Humans

Predicted data for target chemical

2

Other

retinal toxicity that damages RPE and photoreceptor cells

 

Humans

Data from publication for CAS: 7758-05-6

3

Other

retinal toxicity that damages RPE and photoreceptor cells

 

Humans

Data from publication for CAS: 7758-05-6

4

Other

retinal toxicity that damages RPE and photoreceptor cells

 

Humans

Data from publication for CAS: 7758-05-6

5

Other

retinal toxicity that damages RPE and photoreceptor cells

 

Humans

Data from publication for CAS: 7758-05-6

6

Other

retinal toxicity that damages RPE and photoreceptor cells

 

Humans

Data from publication for CAS: 7758-05-6

 

 

Based on the results summarized in above tables for the target chemical Calcium iodate and read across, it can be concluded that the substance causes retinal toxicity that damages RPE and photoreceptor cells in humans.Thus based on this results Calcium iodate is considered to be irritant as the criteria for CLP regulation.

Justification for selection of skin irritation / corrosion endpoint:
Potassium iodate is found to be irritant to skin and mucous membranes of humans

Justification for selection of eye irritation endpoint:
Calcium iodate can produce retinal toxicity that damages RPE and photoreceptor cells. The recovery of retinal function depends on the amount of chemical absorption, the regeneration of RPE, and the recovery function of photoreceptor cells.

Effects on skin irritation/corrosion: irritating

Effects on eye irritation: irritating

Justification for classification or non-classification

According to new CLP regulation classification criteria and based on the values of skin and eye irritation, it is concluded that the substance calcium iodate is not classified as skin irritation category 2 and eye irritation Category 2A.