Calcium iodate

Endpoint summary

Description of key information

Calcium iodate does not exhibits acute toxicity by any of the routes.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records

Reference

Endpoint:

acute toxicity: oral

Type of information:

(Q)SAR

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

GLP compliance:

no

Test type:

standard acute method

Species:

mouse

Strain:

Swiss

Sex:

male/female

Route of administration:

oral: drinking water

Vehicle:

unchanged (no vehicle)

Doses:

no data

No. of animals per sex per dose:

no data

Control animals:

not specified

Sex:

male/female

Dose descriptor:

LD50

Effect level:

358.667 mg/kg bw

Based on:

test mat.

The prediction was based on dataset comprised from the following descriptors: LD50
Estimation method: Taking average value from the 5 nearest neighbours


("a" and "b" )

Domain logical expression index: "a"

Parametric boundary:The target chemical should have a value of log Kow which is >= -7.18

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is <= -7.18

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The acute oral median lethal dose (LD50) of calcium iodate in Swiss mouse was estimated to be 358.6667 mg/kg of body weight.

Executive summary:

The acute oral median lethal dose (LD50) of calcium iodate in Swiss mouse was estimated to be 358.6667 mg/kg of body weight. This value suggest that Calcium iodate exhibits acute toxicity in the Category 4 which is relatively non toxic.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

LD50

Value:

358.667 mg/kg bw

Quality of whole database:

The data is K2 level as the data has been obtained from QSAR model considered reliable by OECD.

Acute toxicity: via inhalation route

Link to relevant study records

Reference

Endpoint:

acute toxicity: inhalation

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

other:

Endpoint conclusion

Endpoint conclusion:

no study available

Acute toxicity: via dermal route

Link to relevant study records

Reference

Endpoint:

acute toxicity: dermal

Type of information:

(Q)SAR

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Justification for type of information:

QSAR prediction: migrated from IUCLID 5.6

Qualifier:

according to guideline

Guideline:

other:

Principles of method if other than guideline:

Data is predicted using QSAR toolbox Version 2.3

GLP compliance:

no

Test type:

fixed dose procedure

Species:

other: Human

Strain:

other: not applicable

Sex:

not specified

Type of coverage:

not specified

Vehicle:

not specified

Duration of exposure:

no data

Doses:

no data

No. of animals per sex per dose:

no data

Control animals:

not specified

Sex:

not specified

Dose descriptor:

other: "Discriminating Dose"

Effect level:

1 300 mg/kg bw

Based on:

test mat.

The prediction was based on dataset comprised from the following descriptors: "discriminating dose"
Estimation method: Taking average value from the 5 nearest neighbours


("a" and "b" )

Domain logical expression index: "a"

Parametric boundary:The target chemical should have a value of log Kow which is >= 0.0436

Domain logical expression index: "b"

Parametric boundary:The target chemical should have a value of log Kow which is <= 0.0436

Interpretation of results:

Toxicity Category IV

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The discriminating Dose of potassium iodate in human was found to be 1300 mg/kg of body weight. Acute dermal toxicity of potassium iodate to human by dermal route indicates that this substance exhibits acute toxicity in Category 4.

Executive summary:

The discriminating Dose of potassium iodate in human was found to be 1300 mg/kg of body weight. Acute dermal toxicity of potassium iodate to human by dermal route indicates that this substance exhibits acute toxicity in Category 4.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed

Dose descriptor:

discriminating dose

Value:

1 300 mg/kg bw

Quality of whole database:

The data is K2 level as the data has been obtained from QSAR model considered reliable by OECD.

Additional information

Acute toxicity: oral

Based on the various studies available with Klimish rating 2and 4 for the target substance Calcium iodate and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No	Endpoint	Effect values	Species	Route	Remarks
1	LD50	358.6667 mg/kg	mouse	Oral	Predicted data of target chemical
2	LD50	1177 mg/kg 815 mg/kg 531 mg/kg	mice	Oral intraesophageal	Data of publication for CAS NO 7758-05-6
3	LD50	505 mg/kg	mice	Oral intraesophageal	Data of publication for CAS NO 7681-55-2
4	LD	700 mg/kg	Rabbit	Oral	Data of publication for CAS NO 7681-11-0
5	LD50	200-250 mg/kg	Dog	Oral capsule	Data of publication for CAS NO 7758-05-6
6	other toxicity	260 mg/kg	Human	Oral	Data of publication for CAS NO 7681-11-0

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LD50 value was found to be in the range of 200 to 1177 mg/kg.Also there is evidence of toxicity effect to Human of calcium iodate. Thus according to CLP criteria it is concluded that the substance Calcium iodate exhibits acute toxicity in the Category 4.

 

Acute toxicity: inhalation

This end point was considered for waiver since calcium iodate has negligible vapour pressure and therefore exposure via the inhalation route is will not take place, justifying this end point for waiver.

Acute toxicity: dermal

The acute dermal toxicity values for the target substance are not available. The acute dermal median lethal dose (LD50) value of read across substance is considered for this endpoint. The discriminating dose value of potassium iodate in human were considered for this end point.

The discriminating Dose of potassium iodate in human was found to be 1300 mg/kg of body weight. Acute dermal toxicity of potassium iodate to human by dermal route indicates that this substance exhibits acute toxicity in Category 4.

Justification for selection of acute toxicity – oral endpoint
The acute oral median lethal dose (LD50) of calcium iodate in Swiss mouse was estimated to be 358.6667 mg/kg of body weight. This value suggest that Calcium iodate exhibits acute toxicity in the Category 4 which is relatively non toxic.

Justification for selection of acute toxicity – inhalation endpoint
This end point was considered for waiver since calcium iodate has negligible vapour pressure and therefore exposure via the inhalation route is will not take place, justifying this end point for waiver.

Justification for selection of acute toxicity – dermal endpoint
The discriminating Dose of potassium iodate in human was found to be 1300 mg/kg of body weight. Acute dermal toxicity of potassium iodate to human by dermal route indicates that this substance exhibits acute toxicity in Category 4.

Justification for classification or non-classification

According to new CLP regulation classification criteria and based on the values of acute toxicity via oral, inhalative and dermal route it is concluded that the substance calcium iodate is classified as acutely toxic by oral, inhalation or dermal route in Toxic category 4.