Registration Dossier
Registration Dossier
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EC number: 232-191-3 | CAS number: 7789-80-2
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- (Q)SAR
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: Predicted data
- Title:
- R: QSAR Toolbox 2.3.0.1132 prediction for LD50 read across evaluation for 7789-80-2
- Author:
- Sustainability Support Services (Europe) AB
- Year:
- 2 012
- Bibliographic source:
- QSAR toolbox version 2.3
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Calcium iodate
- EC Number:
- 232-191-3
- EC Name:
- Calcium iodate
- Cas Number:
- 7789-80-2
- Molecular formula:
- Ca.2HIO3
- IUPAC Name:
- calcium iodate
- Details on test material:
- - Name of test material (as cited in study report): Calcium iodate
- Substance type: inorganic
- Physical state: Solid
-SMILES:O=I(=O)O{-}.[Ca]{2+}.O{-}I(=O)=O
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- Swiss
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- unchanged (no vehicle)
- Doses:
- no data
- No. of animals per sex per dose:
- no data
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 358.667 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
The
prediction was based on dataset comprised from the following
descriptors: LD50
Estimation method: Taking average value from the 5 nearest neighbours
("a"
and "b" )
Domain
logical expression index: "a"
Parametric
boundary:The
target chemical should have a value of log Kow which is >= -7.18
Domain
logical expression index: "b"
Parametric
boundary:The
target chemical should have a value of log Kow which is <= -7.18
Applicant's summary and conclusion
- Interpretation of results:
- Toxicity Category IV
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The acute oral median lethal dose (LD50) of calcium iodate in Swiss mouse was estimated to be 358.6667 mg/kg of body weight.
- Executive summary:
The acute oral median lethal dose (LD50) of calcium iodate in Swiss mouse was estimated to be 358.6667 mg/kg of body weight. This value suggest that Calcium iodate exhibits acute toxicity in the Category 4 which is relatively non toxic.
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