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Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Short-term toxicity to fish

Based on the various studies available with Klimish rating 2and 4 for the target substance Calcium iodate and read across substances and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

LC0

100 mg/l

mortality

96 hrs

Danio rerio

Study Report for target chemical

2

NOEC

100 mg/l

mortality

7 days

Danio rerio

Study Report for target chemical

3

LC50

558.5557 mg/l

mortality

96 hrs

Oncorhynchus mykiss

Predicted data for target chemical

4

LC50

350 mg/l

mortality

96 hrs

Oncorhynchus mykiss

Data from publication for CAS no 7681-55-2

5

LC50

896 mg/l

mortality

96 hrs

Oncorhynchus mykiss

Data from publication for CAS no 7681-11-0

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that the LC0 value was found to be 100 mg/l in 96 hrs study and the LC50 values was found to be in range of 350 to 896 mg/l in 96 hrs on the basis of mortality effect . Thus according to CLP criteria of aquatic classification it is concluded that the substance Calcium iodate is not toxic to Fish (Danio rerio, Oncorhynchus mykiss)

Long-term toxicity to fish

According to annex IX of column I ; Long-term toxicity testing on fish need not to be conducted as it is already provided as a part of Annex VII requirements.Therefore this study was considered to be waived.

Short-term toxicity to aquatic invertebrates

Based on the various studies available with Klimish rating 2 for the read across substances for CAS NO 7789-80-2 and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

LC50

236.1352 mg/l

mortality

48 hrs

Daphnia magna

Predicted data for target chemical

2

LC50

226 mg/L.

 

mortality

24 hrs

Dreissena polymorpha

Data from publication for CAS no 7681-11-0

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that LC50 value is expected to be in range of 226 to 236.1352 mg/l in a 24 to 48 hrs study on the basis of mortality effect . Thus according to CLP criteria of aquatic classification it is concluded that the substance calcium iodate is not toxic to aquatic invertebrate (Daphnia magna and Dreissena polymorpha)

Long-term toxicity to aquatic invertebrates

According to annex IX of column I; Long-term toxicity testing on invertebrate (species: Daphnia) need not to be conducted as it is already provided as a part of Annex VII requirements.Therefore this study was considered waived.

Toxicity to aquatic algae and cyanobacteria

Based on the various studies available with Klimish rating 2 for the read across substances for CAS NO 7789-80-2 and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

MIC

843.1238 mg/l

growth rate

10 days

Dunaliella salina

Predicted data for target chemical

2

MIC

1124.559 mg/l

growth rate

10 days

Cryptomonas sp.

Predicted data for target chemical

3

MIC

2600.4mg/l

growth rate

10 days

N. closterium

Data from publication for CAS no 7681-11-0

4

MIC

2590.7mg/l

growth rate

10 days

Phaedactylum tricornutum

Data from publication for CAS no 7681-11-0

5

MIC

696.2mg/l

growth rate

10 days

Chlorella sp.

Data from publication for CAS no 7681-11-0

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that MIC (Minimum Inhibitory Concentration) value is expected to be in range of696.2 to2600.4 mg/l. Thus considering CLP Criteria for aquatic classification of the substance, it is concluded that Calcium iodate does not exhibit toxicity to green algae (Dunaliella salina, Cryptomonas sp,  N. closterium, Phaedactylum tricornutum, Chlorella sp.)

Toxicity to microorganisms

Based on the various studies available with Klimish rating 2 for the read across substances for CAS NO 7789-80-2 and based on the category approach of organic functional group along with similar mechanistic approach and having structural similarities defined by QSAR toolbox. The results is summarized as follows

 

Sr.No

Endpoint

Effect values

Basis for effects

Duration

Species

Remarks

1

MIC

509.603 mg/l

growth inhibition

24 hrs

Clostridium sp.

Predicted data for target chemical

2

MIC

518.4457 mg/l

growth inhibition

24 hrs

Escherichia coli (JKE029)

Predicted data for target chemical

3

MIC

358.3 mg/l

growth inhibition

24 hrs

Staphylococcus auerus (JKB068

Data from publication for CAS no 7681-11-0

4

MIC

219.4 mg/l

growth inhibition

24 hrs

Escherichia coli (JKE029)

Data from publication for CAS no 7681-11-0

5

MIC

147.6 mg/l

growth inhibition

24 hrs

Bacillus subitilis (JKS007)

Data from publication for CAS no 7681-11-0

6

MIC

231.5 mg/l

growth inhibition

24 hrs

Clostridium sp. 1

Data from publication for CAS no 7681-11-0

7

MIC

200.9 mg/l

growth inhibition

24 hrs

Clostridium sp. 2

Data from publication for CAS no 7681-11-0

 

By applying weight of evidence approach to the studies summarized in the above table it can be observed that MIC (Minimum Inhibitory Concentration) value is expected to be in range of147.6 to 518.4457 mg/l.