Registration Dossier
Registration Dossier
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EC number: 433-480-9 | CAS number: 623-53-0
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Summarised information in a secondary source which is an official US State regulatory review
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Office of Environmental Hazard Assessment Final Revised Health Assessment for Dimethyl Carbonate
- Author:
- Californian Environmental Protection Agency
- Year:
- 2 010
- Bibliographic source:
- OEHHA Assessment, Appendix B
Materials and methods
- Principles of method if other than guideline:
- Statement of dimethyl carbonate metabolites used for calculation of interim Reference Exposure Level value
Test material
- Reference substance name:
- Dimethyl carbonate
- EC Number:
- 210-478-4
- EC Name:
- Dimethyl carbonate
- Cas Number:
- 616-38-6
- Molecular formula:
- C3H6O3
- IUPAC Name:
- dimethyl carbonate
- Details on test material:
- Dimethyl carbonate
Constituent 1
Results and discussion
Metabolite characterisation studies
- Metabolites identified:
- yes
- Details on metabolites:
- Statement: "One mole of dimethyl carbonate is degraded to two moles of methanol plus one mole of carbon dioxide".
Applicant's summary and conclusion
- Conclusions:
- In this regulatory review of dimethyl carbonate it is assumed that mammalian metabolism will be via enzymic hydrolysis, forming methanol and carbon dioxide. Comparable metabolism of ethyl methyl carbonate would form ethanol, methanol and carbon dioxide.
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