Registration Dossier
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EC number: 204-485-1 | CAS number: 121-60-8
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- long-term toxicity to aquatic invertebrates
- Type of information:
- calculation (if not (Q)SAR)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- Data is from computational model developed by USEPA
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling database
- Principles of method if other than guideline:
- Estimation 21 days NOEC value of test chemical on aquatic invertebrates by EPI Suite ECOSAR version 1.11.
- GLP compliance:
- no
- Analytical monitoring:
- no
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Water flea - Test type:
- flow-through
- Water media type:
- freshwater
- Total exposure duration:
- 21 d
- Reference substance (positive control):
- no
- Key result
- Duration:
- 21 d
- Dose descriptor:
- NOEC
- Effect conc.:
- 9.788 mg/L
- Nominal / measured:
- estimated
- Conc. based on:
- test mat.
- Basis for effect:
- reproduction
- Remarks on result:
- other: Neutral Organic SAR (Baseline Toxicity)
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Based on effect of test chemical on the reproduction of the test organism Daphnia magna, the 21 days NOEC value was estimated to be 9.788 mg/l.
- Executive summary:
The long-term toxicity of the test chemical to aquatic invertebrates was predicted using EPI Suite ECOSAR version 1.11. On the basis of effect of test chemical observed in a flow through system on the reproduction of the test organism during the 21 days exposure duration, the NOEC value for the test chemical was estimated to be 9.788 mg/l. Thus, based on the NOEC value, test chemical was considered as non-toxic to aquatic invertebrates and hence, considered to be 'not classified' as per the CLP classification criteria.
Reference
Description of key information
The long-term toxicity of the test chemical to aquatic invertebrates was predicted using EPI Suite ECOSAR version 1.11. On the basis of effect of test chemical observed in a flow through system on the reproduction of the test organism during the 21 days exposure duration, the NOEC value for the test chemical was estimated to be 9.788 mg/l. Thus, based on the NOEC value, test chemical was considered as non-toxic to aquatic invertebrates and hence, considered to be 'not classified' as per the CLP classification criteria.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 9.788 mg/L
Additional information
The long-term toxicity of the test chemical to aquatic invertebrates was predicted using EPI Suite ECOSAR version 1.11. On the basis of effect of test chemical observed in a flow through system on the reproduction of the test organism during the 21 days exposure duration, the NOEC value for the test chemical was estimated to be 9.788 mg/l. Thus, based on the NOEC value, test chemical was considered as non-toxic to aquatic invertebrates and hence, considered to be 'not classified' as per the CLP classification criteria.
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