Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 276-017-4 | CAS number: 71786-67-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1985
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 985
- Report date:
- 1985
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- not specified
- GLP compliance:
- yes
Test material
- Reference substance name:
- Benzyl(3-hydroxyphenacyl)methylammonium chloride
- EC Number:
- 276-017-4
- EC Name:
- Benzyl(3-hydroxyphenacyl)methylammonium chloride
- Cas Number:
- 71786-67-9
- Molecular formula:
- C16H17NO2.ClH
- IUPAC Name:
- benzyl(3-hydroxyphenacyl)methylammonium chloride
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Himalayan
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Fa. Thomae, Biberach
- Age at study initiation: 24 - 26 weeks
- Weight at study initiation: 2.1 - 2.3 kg
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 - 26
- Humidity (%): 50 - 65
- Photoperiod (hrs dark / hrs light): 12:12
Test system
- Type of coverage:
- other: occulsive and semi-occulsive
- Preparation of test site:
- clipped
- Vehicle:
- physiological saline
- Controls:
- yes
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 g
VEHICLE
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- 1 week
- Number of animals:
- 6 animals ( 3 male and 3 female )
- Details on study design:
- TEST SITE
- Area of exposure: 3 x 3 cm
- Type of wrap if used: gauze bandage
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with water
- Time after start of exposure: 4 h
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: all animals
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal: all animals
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal: all animals
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Basis:
- animal: all animals
- Time point:
- other: 7 d
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: all animals
- Time point:
- other: 1 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: all animals
- Time point:
- other: 24 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: all animals
- Time point:
- other: 72 h
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- animal: all animals
- Time point:
- other: 7 d
- Score:
- 0
- Max. score:
- 4
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information
- Conclusions:
- Die okkulsive bzw. semiokkulsiv epikutane Applikation von Benzyladrianonhydrochlorid während einer Dauer von vier Stunden auf gesunder
Kanninchenhaut rief be den 6 untersuchten Tieren keine Zeichen von primärer Hautreizung ( Erythem oder Ödem ) während einer Beobachtungsperiode von 1 Stunde bis 7 Tagen nach Applikationsende hervor.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
