Registration Dossier
Registration Dossier
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EC number: 224-481-3 | CAS number: 4378-61-4
Endpoint summary
Administrative data
Description of key information
Additional information
The acute toxicity of the test item to fish (zebrafish) was determined according to OECD-Guideline for Testing of Chemicals No. 203 (1992). A semi-static limit test with daily renewal of the test media was conducted with a saturated solution of 1.00 mg/L of the test item.
The saturated solution of the test item didn´t show any signs of toxicity nor lethality at all observation time points up to 96 hours. Therefore, the NOEC and LC0were laid down as >= 1.00 mg/L (based on the nominal concentration) and LC100was laid down as > 1.00 mg/L (based on the nominal concentration).
The substance is highly insoluble in water. As recommended the long-term aquatic toxicity study on aquatic invertebrates was conducted. Testing of the short-term toxicity is therefore not required according to column 2 of Annex VII (section 9.1.1.) of Regulation (EC) No 1907/2006.
The Daphnia magna Reproduction Test (semi-static, 21 d) of the test item was conducted as a limit test with the saturated solution of 1.00 mg/L according to OECD 211 (2008). The test method was semi-static with a daily renewal of the test solutions. The aim of the Daphnia Reproduction Test over 21 days was to assess effects on the reproduction capacitiy and other test item-related effects, including occurence of aborted eggs and stillborn juveniles, time of production of first brood, adult mortality, intrinsic rate of natural increase, dry body weight and length of the parent daphnids. At the saturated solution of the test item with a nominal loading of 1.00 mg/L no significant effects were determined.
The No Observed Effect Loading Level (NOEL) and the Lowest Observed Effect Loading Level (LOEL) were assessed at NOEL: 1.00 mg/L; LOEL: > 1.00 mg/L.
The toxicity of the test item to the unicellular freshwater green alga Desmodesmus subspicatus was determined according to OECD 201 (2006). The study was conducted under static conditions with a saturated solution of 1.00 mg/L of the test item. In this study the test item did not cause any inhibiting effects to Desmodesmus subspicatus after 72 h.
The No Observed Effect Loading Level (NOEL) and the Lowest Observed Effect Loading Level (LOEL) were assessed at NOEL: 1.00 mg/L; LOEL: > 1.00 mg/L.
A respiration inhibition test with activated sludge according to OECD 209 (2010) was performed under static conditions with the nominal limit concentration of 1000 mg/L. The test item caused no inhibiting effects at a concentration of 1000 mg/L to activated sludge of a municipal sewage treatment plant. The NOEC is 1000 mg/L.
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