Registration Dossier
Registration Dossier
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EC number: 222-695-1 | CAS number: 3576-88-3
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 2009
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: This is a recent guideline study under GLP, but only an English summary of the Chinese report is available.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 009
- Report date:
- 2009
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Guideline for testing of Chemicals 2004, No 402, China.
- Deviations:
- not specified
- Principles of method if other than guideline:
- The method used resembles the OECD 402 method.
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- 2,2'-iminobis[4,6-diamino-1,3,5-triazine]
- EC Number:
- 222-695-1
- EC Name:
- 2,2'-iminobis[4,6-diamino-1,3,5-triazine]
- Cas Number:
- 3576-88-3
- Molecular formula:
- C6H9N11
- IUPAC Name:
- N~2~-(4,6-diamino-1,3,5-triazin-2-yl)-1,3,5-triazine-2,4,6-triamine
Constituent 1
Test animals
- Species:
- rat
- Sex:
- male/female
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- petrolatum
- Details on dermal exposure:
- The sample was fixed by vaseline, then the skin was isolated by covering a box for 24 h.
- Duration of exposure:
- 24 h.
- Doses:
- 2500 mg/kg bw.
- No. of animals per sex per dose:
- 5 m + 5 f.
- Control animals:
- yes
- Statistics:
- Performed.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No.
- Gross pathology:
- No significant gross lesions were observed.
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The LD50 was greater than 2500 mg/kg bw.
- Executive summary:
5 male + 5 female rats were dosed with 2500 mg/kg bw dermally and observed for 14 days. A control group was used too.
No significant toxic signs were observed and no abnormalities were detected at necropsy. The LD50 was greater than 2500 mg/kg bw.
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