Registration Dossier
Registration Dossier
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EC number: 222-695-1 | CAS number: 3576-88-3
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Study period:
- 2011
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction: migrated from IUCLID 5.6
Data source
Reference
- Reference Type:
- other: QSAR calculation
- Title:
- Unnamed
- Year:
- 2 011
- Report date:
- 2011
Materials and methods
- Principles of method if other than guideline:
- The Dermal Permeability Coefficient Program (DERMWIN) v2.00 was used to calculate the dermal permeability coefficient (Kp), the dermally absorbed dose per event (DAevent) and Dermal Absorbed Dose (DAD) of organic compounds via water contact.
- GLP compliance:
- no
Test material
- Reference substance name:
- melam
- IUPAC Name:
- melam
- Reference substance name:
- n(c(nc(n1)Nc(nc(nc2N)N)n2)N)c1N
- IUPAC Name:
- n(c(nc(n1)Nc(nc(nc2N)N)n2)N)c1N
Constituent 1
Constituent 2
- Radiolabelling:
- no
Results and discussion
Applicant's summary and conclusion
- Conclusions:
- The dermal permeability coefficient (Kp) is predicted to 1.62e-005 cm/h.
Dermally Absorbed Dose (70 kg Adult) - Water Contact:
Result: DAD = 1.32e-004 mg/kg-day - Executive summary:
The Dermal Permeability Coefficient Program (DERMWIN) v2.00 estimates the dermal permeability coefficient (Kp), the dermally absorbed dose per event (DAevent) and Dermal Absorbed Dose (DAD) of organic compounds via water contact.
The dermal permeability coefficient (Kp) was predicted to 1.62e-005 cm/h.
Dermally Absorbed Dose (DA) per Event for Organic Compounds - Water Contact:
DA(event) = 1.25e-006 mg/cm2.
Dermally Absorbed Dose (DAD) (70 kg Adult) - Water Contact:
DAD = 1.32e-004 mg/kg-day
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