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EC number: 278-145-6 | CAS number: 75234-41-2
Acid Brown 425 is produced and handled as a dye for leather. The material is a 2 to 1 complex of chromium 3+and the products of an azo-coupling reaction of resorcinol with amino-toluene sulfonic acid and anthranilic acid. The material is a mixture of different sulfonic acid salts with highly polar characters.
The molecular weight range of this material is between about 500 and 1500 Daltons. It contains about 5 - 6 % sodium sulfate and sodium chloride and 6 % water.
Absorption: Acid Brown 425 is easily soluble in water. The solution shows a pH value of around 6. The material is expected to be readily bio-available at the portal of entry and at least partly systemically after oral exposure. Little bio-availability is expected after dermal exposure due to the polar nature of the dye.
Distribution: Due to the good solubility of the dye in water at least the smaller variants of the dye molecules are expected to be distributed to some degree throughout the organism. Due to their high molecular weight and their polarity little distribution beyond the portal of entry is expected for those variants with molecular weights above 1000 Dalton. Accumulation in fatty tissue however is not expected based on the very polar sulfonic acid moieties in the molecules.
Metabolism: Acid Brown 425 has a molecular weight between 500 and 1500 Dalton and is very soluble at physiologic pH. Significant metabolism is expected if the substrate is soluble in water at physiological pH and is transported through biological membranes into cells. Due to the high polarity and the good solubility such transport is not very likely for the larger variants, although the smaller variants of the dye may partially become bio-available. Significant metabolism is, however, considered unlikely.
Excretion: As Acid Brown 425 is easily soluble in water the dye is expected to be excreted via the kidney. If applied orally part of the material will be eliminated via the feces. After skin exposure material not removed by washing will be eliminated via the natural turnover of skin cells.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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