Registration Dossier

Administrative data

First-aid measures

INHALATION: Remove to fresh air. If any trouble breathing, get immediate medical attention. Administer artificial
respiration if breathing has ceased. If irritation or symptoms occur or persist, consult a physician.

SKIN CONTACT: In case of skin contact, w hile w earing protective gloves, carefully remove any contaminated clothing,
including shoes, and w ash skin thoroughly w ith soap and w ater. If irritation or symptoms occur or
persist, consult a physician.

EYECONTACT: In case of eye contact, immediately rinse eyes thoroughly w ith plenty of w ater. If w earing contact
lenses, remove only after initial rinse, and continue rinsing eyes for at least 15 minutes. If irritation
occurs or persists, consult a physician.

INGESTION: Rinse mouth and drink a glass of w ater. Do not induce vomiting unless under the direction of a qualified
medical professional or Poison Control Center. If symptoms persist, consult a physician.

NOTETO PHYSICIAN: This material is being evaluated for use as a pharmaceutical agent or in the manufacture of a
pharmaceutical agent. No antidotes have been identified.


Fire-fighting measures

SPECIAL FIREFIGHTING PROCEDURES:
Wear full protective clothing and self-contained breathing apparatus (SCBA).

SUITABLEEXTINGUISHING MEDIA:
Carbon dioxide (CO2), extinguishing pow der or w ater spray.

Accidental release measures

PERSONAL PRECAUTIONS:
Avoid generation of dust during clean-up. Wear appropriate personal protective equipment. Keep personnel aw ay fromthe
clean-up area.

SPILL RESPONSE/ CLEANUP:
All spills should be handled according to site requirements. In the case of liquids, use proper absorbent
materials. For laboratories and small-scale operations, incidental spills w ithin a hood or enclosure should be cleaned by using a HEPA filtered vacuum
or w et cleaning methods as appropriate. For large dry or liquid spills or those spills outside enclosure or hood, appropriate emergency response
personnel should be notified. In manufacturing and large-scale operations, HEPA vacuuming prior to w et mopping or cleaning is required.

Handling and storage

HANDLING:
Keep containers adequately sealed during material transfer, transport, or w hen not in use.
Appropriate handling of this material is dependent on many factors, including physical form, duration and frequency of process or task, and
effectiveness of engineering controls. Site-specific risk assessments should be conducted to determine the feasibility and the appropriateness of all
exposure control measures.

STORAGE:
Store in a cool, dry, w ell ventilated area.

Transport information

Land transport (ADR/RID)

UN number:
Not classified for transportation
Shippingopen allclose all
Class:
Not classified for transportation
Classification code:
Not classified for transportation
Packaging group:
Not classified for transportation
Labels:
Not classified for transportation
SpecialProvisionsopen allclose all

Inland waterway transport (ADN(R))

UN number:
Not classified for transportation
Shippingopen allclose all
Class:
Not classified for transportation
Classification code:
Not classified for transportation
Packaging group:
Not classified for transportation
Labels:
Not classified for transportation
Remarksopen allclose all

Marine transport (IMDG)

UN number:
Not classified for transportation
Proper shipping name and description:
Not classified for transportation
Chemical name:
Not classified for transportation
Class:
Not classified for transportation
Packaging group:
Not classified for transportation
EmS code:
Not classified for transportation
Labels:
Not classified for transportation
Remarksopen allclose all

Air transport ICAO/IATA

UN number:
Not classified for transportation
Proper shipping name and description:
Not classified for transportation
Chemical name:
Not classified for transportation
Class:
Not classified for transportation
Packaging group:
Not classified for transportation
Labels:
Not classified for transportation
Remarks
Not classified for transportation
SpecialProvisionsopen allclose all

Exposure controls / personal protection

EXPOSURE CONTROLS:
The health hazard risks of handling this material are dependent on many factors, including physical form, duration and frequency of process or task,
and effectiveness of engineering controls. Site-specific risk assessments should be conducted to determine the feasibility and the appropriateness
of all exposure control measures. Exposure controls for normal operating or routine procedures follow a tiered strategy. Engineering controls are
the preferred means of long-termor permanent exposure control. If engineering controls are not feasible, appropriate use of personal protective
equipment (PPE) may be considered as alternative control measures. Exposure controls for non-routine operations must be evaluated and
addressed as part of the site-specific risk assessment.

Respiratory Protection: Respiratory protective equipment (RPE) may be required for certain laboratory and large-scale
manufacturing tasks if potential airborne breathing zone concentrations of substances exceed the
relevant exposure limit(s). Workplace risk assessment should be completed before specifying and
implementing RPE usage. Potential exposure points and pathw ays, task duration and frequency,
potential employee contact w ith the substance, and the ability of the substance to be rendered airborne
during specific tasks should be evaluated. Initial and ongoing strategies of quantitative exposure
measurement should be obtained as required by the w orkplace risk assessment. All RPE must conform
to local and regional specifications for efficacy and performance. Consult your site or corporate health
and safety professional for additional guidance.

Skin Protection: Gloves that provide an appropriate barrier to the skin are recommended if there is potential for contact
w ith this material. Consult your site safety staff for guidance.

Eye Protection: Safety glasses w ith side shields. Use of goggles or full face protection may be required based on
hazard, potential for contact, or level of exposure. Consult your site safety staff for guidance.

Body Protection: In small-scale or laboratory operations, lab coats or equivalent protection is required. Disposable Tyvek
or other dust impermeable suit should be considered based on procedure or level of exposure. Use of
additional PPEsuch as shoe coverings, gauntlets, hood, or head covering may be necessary. Consult
your site safety staff for guidance.
In large-scale or manufacturing operations, disposable Tyvek or other dust impermeable suit is
recommended and based on level of exposure. Use of additional PPEsuch as shoe coverings,
gauntlets, hood, or head covering may be necessary. Consult your site safety staff for guidance.

Stability and reactivity

STABILITY/ REACTIVITY:
Stable under normal conditions.

INCOMPATIBLEMATERIALS / CONDITIONS TO AVOID:
None know n.

HAZARDOUS DECOMPOSITION PRODUCTS / REACTIONS:
No dangerous decomposition is expected if used according to manufacturer's specifications.

Disposal considerations

MATERIAL WASTE:
Disposal must be in accordance w ith applicable federal, state/provincial, and/or local regulations. Incineration is the preferred method of disposal,
w hen appropriate.