Registration Dossier
Registration Dossier
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EC number: 237-048-9 | CAS number: 13597-46-1
Endpoint summary
Administrative data
Key value for chemical safety assessment
Genetic toxicity in vitro
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (negative)
Additional information
Justification for classification or non-classification
Zinc selenite did not show a significant or dose-dependent increase in mutations in cultured mouse lymphoma cells (L5178Y) up to the maximum dose of 120 µg/mL.
Based on the weight of the evidence from the existing in vitro and in vivo genotoxicity assays with zinc and selenium compounds, it is concluded that zinc selenite does not have biologically relevant genotoxic activity. Consequently, no classification for germ cell mutagenicity is applicable.
This conclusion is in line with those achieved by other regulatory reviews of the genotoxicity of zinc compounds (WHO, 2001; SCF, 2003; EU RAR, 2004, MAK, 2009). Hence, no classification and labelling for mutagenicity is required.
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