Benzene, ethenyl-, ar-bromo derivs.

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

28 August 2003 to 13 November 2003

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: Study conducted in compliance with agreed protocols, with no or minor deviations from standard test guidelines and/or minor methodological deficiencies, which do not affect the quality of the relevant results.

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7840 (Water Solubility)

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

GLP compliance:

yes

Type of method:

flask method

Water solubility:

6.91 mg/L

Conc. based on:

test mat.

Loading of aqueous phase:

5 other: mg/DBSL

Incubation duration:

>= 24 - <= 48 h

Temp.:

20 °C

Remarks on result:

other: pH not determined

Details on results:

Duplicate sub-samples were removed from the appropriate bottles after 24 and 48 hours of shaking in a water bath maintained at 30 ± 1.0°C and following 24 hours of equilibration at 20 ± 0.5°C. Analysis of these aqueous sub-samples yielded water solubility concentrations for DBS that were dependent on the component of the DBS test substance being monitored. Mean measured DBS concentrations for the 24 and 48-hour samples were well within the 15% criterion of the protocol. Consequently, analysis of the 72-hour sample was not required. The mean water solubility (n = 4) for DBS at 20 ºC were 6.91 ± 0.0871, 49.2 ± 1.45, and 1.03 ± 0.104 mg/L using the dibromo-, monobromo-, and tribromostyene as surrogates for the test substance, respectively, to quantitate DBS concentrations. For the dibromo-, monobromo-, and tribromostyrene components, the CV for the measured solubilities were 1.26%, 2.95%, and 10.1%, respectively.

No further information required.

Conclusions:

Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L) for all 3 components: dibromo-, monobromo-, and tribromostyrene
The solubility of DBS in HPLC-grade bottled reagent water was dependent on the component of the DBS test substance being monitored. The mean water solubility for DBS at 20 ºC was 6.91 ± 0.0871, 49.2 ± 1.45, and 1.03 ± 0.104 mg/L using the dibromo-, monobromo-, and tribromostyene surrogates for the test substance, respectively, to quantitate DBS concentrations.

Executive summary:

In line with OCED Guideline 105, the water solubility of DBS was determined using the shake-flask method. The solubility of DBS in HPLC-bottled reagent water was dependent on the component of DBS test substance being monitored. The mean water solubility (n=4) for DBS at 20 ºC was 6.91 ± 0.0871, 49.2 ± 1.45 and 1.03 ± 0.104 mg/L using the dibromostyrene, monobromostyrene and tribromostyrene surrogates for the test substance, respectively, to quantitate DBS concentrations.

Description of key information

The solubility of DBS in HPLC-grade bottled reagent water was dependent on the component of the DBS test substance being monitored. The mean water solubility for DBS at 20 ºC was 6.91 ± 0.0871, 49.2 ± 1.45, and 1.03 ± 0.104 mg/L using the dibromo-, monobromo-, and tribromostyene surrogates for the test substance, respectively, to quantitate DBS concentrations.

Key value for chemical safety assessment

Water solubility:

6.91 mg/L

at the temperature of:

20 °C

Additional information

The key study for this endpoint, Van Hoven, R.L. & Nixon, W.B. (2003) was performed in accordance with OECD guideline 105 and in compliance with GLP and was considered of a high reliability. Accordingly, the study was assigned a reliability score of 1 and was considered adequate for use as a standalone study to represent the water solubility of the substance.