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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Repeated dose toxicity: oral

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Administrative data

Endpoint:
short-term repeated dose toxicity: oral
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1966
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
documentation insufficient for assessment

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1966
Report date:
1966

Materials and methods

Test guideline
Qualifier:
no guideline available
Principles of method if other than guideline:
see below
GLP compliance:
no
Limit test:
yes

Test material

Constituent 1
Reference substance name:
3-methoxybutanol
IUPAC Name:
3-methoxybutanol
Constituent 2
Chemical structure
Reference substance name:
3-methoxybutan-1-ol
EC Number:
219-741-8
EC Name:
3-methoxybutan-1-ol
Cas Number:
2517-43-3
Molecular formula:
C5H12O2
IUPAC Name:
3-methoxybutan-1-ol
Details on test material:
No data

Test animals

Species:
rat
Strain:
other: Albino mixed race
Sex:
not specified
Details on test animals or test system and environmental conditions:
weight: 83g - 109 g
Housing: cage (metal)

Administration / exposure

Route of administration:
oral: gavage
Details on route of administration:
10% in drinking water administered via gavage.
Vehicle:
water
Details on oral exposure:
1 g /kg be
Analytical verification of doses or concentrations:
not specified
Duration of treatment / exposure:
once per day on 14 days within a period of 16 days.
Frequency of treatment:
see above
Doses / concentrations
Dose / conc.:
1 000 mg/kg bw/day (actual dose received)
Control animals:
not specified
Details on study design:
No further details specified.
Positive control:
No further details specified.

Results and discussion

Results of examinations

Clinical signs:
no effects observed
Description (incidence and severity):
not applicable
Mortality:
no mortality observed
Body weight and weight changes:
effects observed, non-treatment-related
Description (incidence and severity):
Normal weight increase obsereved.
Food efficiency:
not specified
Water consumption and compound intake (if drinking water study):
not specified
Ophthalmological findings:
no effects observed
Haematological findings:
no effects observed
Clinical biochemistry findings:
no effects observed
Urinalysis findings:
not examined
Description (incidence and severity):
Normal excretion
Behaviour (functional findings):
no effects observed
Immunological findings:
not specified
Organ weight findings including organ / body weight ratios:
no effects observed
Gross pathological findings:
no effects observed
Neuropathological findings:
not specified
Histopathological findings: non-neoplastic:
no effects observed
Histopathological findings: neoplastic:
no effects observed
Other effects:
no effects observed

Any other information on results incl. tables

No effects were observed during treatment and during the observation period of five days. Animals had normal excretion and a normal increase of weight. The blood analysis showed no pathological observation. The macroscopic and histologic examination of the organs (heart, lung, liver, kidney, and spleen) showed no changes.

Applicant's summary and conclusion

Conclusions:
No effects were observed during treatment and during the observation period of five days. Animals had normal excretion and a normal increase of weight. The blood analysis showed no pathological observation. The macroscopic and histologic examination of the organs (heart, lung, liver, kidney, and spleen) showed no changes.