Registration Dossier
Registration Dossier
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EC number: 219-741-8 | CAS number: 2517-43-3
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
No in vivo tests are available for 3-methoxybutan-1-ol, however information is presented below from structural alert considerations and results of in vivo sensitisation tests on a structurally similar substance.
Structural alerts
With its simple alkyl backbone, lack of functionality to allow binding to protein, there is no obvious structural alert for sensitisation with 3-methoxybutan-1-ol (Ashby et. al., 1995; OECD, 2009).
Similar chemistryNo in vivo tests are available for 3-methoxybutan-1-ol. However the close structural analogue 3-methoxy-3-methyl-1-butanol, differing only by a single methyl group, has been tested in vivo and negative results reported for sensitisation (OECD, 2004).
n-Butyl acetate has been tested in vivo and reported to be negative (Gad et al., 1986). This would be expected to be rapidly metabolised to butanol.
For 3-methoxybutan-1-ol, consideration of structural alerts and results of in vivo sensitisation assays for similar chemistry reveal enough evidence to conclude that 3-methoxybutan-1-ol is devoid of dermal sensitising potential. CitationsDupuis, G. and Benezra, C. (1982) Allergic Contact Dermatitis to Simple Chemicals. Marcel Dekker, New York and Basel. (cited by Ashby et al., 1995)
European Union Draft Risk Assessment (2008) Initial risk assessment provided by the rapporteur Member State Germany for the existing active substance Acetic acid of the fourth stage of the review programme referred to in Article 8(2) of Council Directive 91/414/EEC.
Landsteiner, K. and Jacobs, J.L. (1936) Studies on the sensitization of animals with simple chemical compounds III. J. Exp. Med. 64.625-639. (cited by Ashby et al., 1995)
OECD (2004): SIDS for 3-Methoxy-3-methyl-1- butanol, Paris, France, 20-23 April 2004
Migrated from Short description of key information:
The weight of evidence indicates that 3-methoxybutan-1-ol is not a skin sensitiser.
Respiratory sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
Inhalation studies in rats, mice dogs and cats have not highlighted evidence of respiratory sensitisation for 3-methoxybutan-1-ol.
Migrated from Short description of key information:
There is no evidence that 3-methoxybutan-1-ol is a respiratory sensitiser.
Justification for classification or non-classification
According to criteria in Regulation (EC) No.1272/2008, the substance is not classified for skin or respiratory tract sensitisation. The evidence indicates that 3 -methoxybutan-1 -ol does not cause skin or respiratory sensitisation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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