Registration Dossier

Administrative data

Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study according to OECD 107

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report Date:
1997

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
shake-flask method to: flask method
Partition coefficient type:
octanol-water

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
name: Cyanamide, (4,5-dihydroxy-2-thiazolyl)-
molecular formula: C4 H5 N3 S
molecular weight: 127.2
physical state: solid
analytical purity: 99.8 %

Study design

Analytical method:
high-performance liquid chromatography

Results and discussion

Partition coefficientopen allclose all
Type:
log Pow
Partition coefficient:
-0.065
Temp.:
20 °C
Remarks on result:
other: unbuffered solution
Type:
log Pow
Partition coefficient:
-0.06
Temp.:
20 °C
pH:
4
Type:
log Pow
Partition coefficient:
-0.041
Temp.:
20 °C
pH:
7
Type:
log Pow
Partition coefficient:
-0.143
Temp.:
20 °C
pH:
9
Type:
Pow
Partition coefficient:
0.86
Temp.:
20 °C
Remarks on result:
other: unbuffered solution
Type:
Pow
Partition coefficient:
0.87
Temp.:
20 °C
pH:
4
Type:
Pow
Partition coefficient:
0.91
Temp.:
20 °C
pH:
7
Type:
Pow
Partition coefficient:
0.72
Temp.:
20 °C
pH:
9

Applicant's summary and conclusion

Conclusions:
The determination of the partition coefficient of the test substance in octanol-water indicate that there is not bioaccumulation potentiat for the test substance.
Executive summary:

The values found fpr CIT are summarized by the following table:

unbuffered pH4 pH7 pH9
Pow 0.86 0.87 0.91 0.72
log Pow - 0.065 - 0.060 - 0.041 -0.143