Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study according to OECD 105

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report date:
1997

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
flask method

Test material

Constituent 1
Chemical structure
Reference substance name:
-
EC Number:
427-720-1
EC Name:
-
Cas Number:
26364-65-8
Molecular formula:
C4H5N3S
IUPAC Name:
[(1,3-thiazolidin-2-ylidene)amino]formonitrile
Details on test material:
name: Cyanamide, (4,5-dihydroxy-2-thiazolyl)-
molecular formula: C4 H5 N3 S
molecular weight: 127.2
physical state: solid
analytical purity: 99.8 %

Results and discussion

Water solubility
Water solubility:
7 g/L
Temp.:
20 °C
pH:
ca. 6.61 - ca. 7.03

Any other information on results incl. tables

  acidic neutral pH5.5-7 alkaline
  phosphate buffer phosphate buffer unbuffered water borate buffer
  c(NaH2P04 x2H2O) = 0.01 Mole/L adjusted to pH 5 with conc. NaOH c(Na2HPO4x12H2O) = 0.01 Mole/L adjusted to pH 7 with conc. H3PO4 in equilibrium with atmospheric carbon dioxide c(Na2B4O7x10H2O) = 0.01 Mole/L
         
PH 5.0 7.1 (6.8) 8.6
stirring time pH  [ g / L ] pH  [ g / L ] pH  [ g / L ] pH [ g / L ]
0.5 hrs. 5.81 7.5598 7.26 7.7504 6.61 7.1225 8.69 8.6353
1 hr. 5.25 7.9123 7.37 7.8418 6.90 7.0268 8.46 8.8018
2 hrs. 5.47 8.3661 7.19 8.1626 6.70 7.7188 8.59 8.9372
4 hrs. 4.65 7.5388 7.12 7.9965 6.67 7.8048 8.59 9.3456
8 hrs. 4.51 8.1458 7.15 8.0227 6.71 8.3756 8.59 9.4446
24 hrs. 4.37 7.5120 7.19 7.9793 6.91 7.7546 8.60 8.6813
48 hrs. -- -- -- -- 7.03 7.8898 -- --
144 hrs. -- -- -- -- -- -- 8.99 8.2552
mean 7.84 7.96 7.67 8.87
R.S.D. 4.6% 1.8% 6.0% 4.7%

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The solubility of CIT is 7.7 g/L.
Executive summary:

The water solubility determined at 20 °C and as a function of pH according to the OECD

Guidelines No. 105 corresponding to EC Guideline A.6 as described under flask method gave the

following results:

  unbuffered pH5 pH7 pH9
solubility 7.7 g/L 7.8 g/L 8.0 g/L 8.9 g/L