Registration Dossier

Administrative data

Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Study according to OECD 105

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1997
Report Date:
1997

Materials and methods

Test guideline
Qualifier:
according to
Guideline:
OECD Guideline 105 (Water Solubility)
Deviations:
no
GLP compliance:
yes (incl. certificate)
Type of method:
flask method

Test material

Reference
Name:
Unnamed
Type:
Constituent
Details on test material:
name: Cyanamide, (4,5-dihydroxy-2-thiazolyl)-
molecular formula: C4 H5 N3 S
molecular weight: 127.2
physical state: solid
analytical purity: 99.8 %

Results and discussion

Water solubility
Water solubility:
7 g/L
Temp.:
20 °C
pH:
ca. 6.61 - ca. 7.03

Any other information on results incl. tables

  acidic neutral pH5.5-7 alkaline
  phosphate buffer phosphate buffer unbuffered water borate buffer
  c(NaH2P04 x2H2O) = 0.01 Mole/L adjusted to pH 5 with conc. NaOH c(Na2HPO4x12H2O) = 0.01 Mole/L adjusted to pH 7 with conc. H3PO4 in equilibrium with atmospheric carbon dioxide c(Na2B4O7x10H2O) = 0.01 Mole/L
         
PH 5.0 7.1 (6.8) 8.6
stirring time pH  [ g / L ] pH  [ g / L ] pH  [ g / L ] pH [ g / L ]
0.5 hrs. 5.81 7.5598 7.26 7.7504 6.61 7.1225 8.69 8.6353
1 hr. 5.25 7.9123 7.37 7.8418 6.90 7.0268 8.46 8.8018
2 hrs. 5.47 8.3661 7.19 8.1626 6.70 7.7188 8.59 8.9372
4 hrs. 4.65 7.5388 7.12 7.9965 6.67 7.8048 8.59 9.3456
8 hrs. 4.51 8.1458 7.15 8.0227 6.71 8.3756 8.59 9.4446
24 hrs. 4.37 7.5120 7.19 7.9793 6.91 7.7546 8.60 8.6813
48 hrs. -- -- -- -- 7.03 7.8898 -- --
144 hrs. -- -- -- -- -- -- 8.99 8.2552
mean 7.84 7.96 7.67 8.87
R.S.D. 4.6% 1.8% 6.0% 4.7%

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): soluble (1000-10000 mg/L)
The solubility of CIT is 7.7 g/L.
Executive summary:

The water solubility determined at 20 °C and as a function of pH according to the OECD

Guidelines No. 105 corresponding to EC Guideline A.6 as described under flask method gave the

following results:

  unbuffered pH5 pH7 pH9
solubility 7.7 g/L 7.8 g/L 8.0 g/L 8.9 g/L