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EC number: - | CAS number: -
Vapour pressure
Administrative data
Link to relevant study record(s)
- Endpoint:
- vapour pressure
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 9 march 2022 to 12 may 2022
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.4 (Vapour Pressure)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 104 (Vapour Pressure Curve)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- effusion method: Knudsen cell
- Test no.:
- #1
- Temp.:
- 20 °C
- Vapour pressure:
- 0.006 Pa
- Test no.:
- #2
- Temp.:
- 25 °C
- Vapour pressure:
- 0.008 Pa
- Test no.:
- #3
- Temp.:
- 50 °C
- Vapour pressure:
- 0.025 Pa
- Conclusions:
- The vapour pressure of the test item L-Leucine, reaction products with 1,4:3,6-dianhydro-D-glucitol, iso-Pr alc. and octanoyl chloride was calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation (EC) No 440/2008 Method A.4. Vapour pressure and OECD Test Guideline 104 (2006).
20°C 6.2 x 10-3 Pa
25°C 8.0 x 10-3 Pa
50°C 2.5 x 10-2 Pa - Executive summary:
The vapour pressure of the test item L-Leucine, reaction products with 1,4:3,6-dianhydro-D-glucitol, iso-Pr alc. and octanoyl chloride was calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation (EC) No 440/2008 Method A.4. Vapour pressure and OECD Test Guideline 104 (2006).
Temperature / °C Vapour pressure / Pa 20 6.2 x 10-3 25 8.0 x 10-3 50 2.5 x 10-2
Reference
6 Results
6.1 Thermal Stability (DSC)
The DSC run PN23126 is shown in Figure 2. In the temperature range of 130 – 220 °C a broad slight exothermic effect could be observed, with an energy release of -20 J/g. No further effects could be observed. The results of the DSC measurement are summarized in Table 1.
Table 1: Results of the DSC measurement
| Measurement No. | Sample weight / atmosphere | Start / °C | Energy / J/g |
| PN23126 | 5.4 mg / air | 130 (exothermic) | -20 |
6.2 Effusion method: Knudsen cell
The vapour pressure was measured in the temperature range of 24 to 84 °C. The measured vapour pressure values together with the measured temperatures are listed in Table 2.
Table 2: Results of the effusion method
| No. | Temperature / °C | Vapour pressure / Pa |
| 1 | 24.4 | 6.71 x 10-3 |
| 2 | 34.3 | 1.30 x 10-2 |
| 3 | 44.5 | 2.57 x 10-2 |
| 4 | 54.5 | 2.75 x 10-2 |
| 5 | 64.5 | 4.34 x 10-2 |
| 6 | 74.4 | 6.66 x 10-2 |
| 7 | 84.4 | 8.82 x 10-2 |
From the measured data points of the vapour pressure curve the constants A and B of the Antoine equation
log10 p = A + B/T = A + B/(C + θ)
can be derived by regression of the data points to
A = 4.3192
B = -1913.45
C = 273.15.
The vapour pressure of the test item L-Leucine, reaction products with 1,4:3,6-dianhydro-D-glucitol, iso-Pr alc. and octanoyl chloride calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation (EC) No 440/2008 Method A.4. Vapour pressure and OECD Test Guideline 104 (2006) is shown in Table 3.
Table 3: Calculated vapour pressure values for 20, 25 and 50 °C
| Temperature / °C | Vapour pressure / Pa |
| 20 | 6.2 x 10-3 |
| 25 | 8.0 x 10-3 |
| 50 | 2.5 x 10-2 |
6.3 Final Results
The vapour pressure of the test item L-Leucine, reaction products with 1,4:3,6-dianhydro-D-glucitol, iso-Pr alc. and octanoyl chloride was calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation (EC) No 440/2008 Method A.4. Vapour pressure and OECD Test Guideline 104 (2006).
| Temperature / °C | Vapour pressure / Pa |
| 20 | 6.2 x 10-3 |
| 25 | 8.0 x 10-3 |
| 50 | 2.5 x 10-2 |
Description of key information
The vapour pressure of the test item L-Leucine, reaction products with 1,4:3,6-dianhydro-D-glucitol, iso-Pr alc. and octanoyl chloride was calculated by interpolation and extrapolation of the measured vapour pressure curve for the temperatures 20, 25 and 50 °C, according to Regulation (EC) No 440/2008 Method A.4. Vapour pressure and OECD Test Guideline 104 (2006).
| Temperature / °C | Vapour pressure / Pa |
| 20 | 6.2 x 10-3 |
| 25 | 8.0 x 10-3 |
| 50 | 2.5 x 10-2 |
Key value for chemical safety assessment
- Vapour pressure:
- 0.008 Pa
- at the temperature of:
- 25 °C
Additional information
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