Registration Dossier
Registration Dossier
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EC number: 448-060-0 | CAS number: 727678-39-9
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
ErC50 (72 h) > 0.02 mg/L (measured concentration) based on growth rate.
Key value for chemical safety assessment
Additional information
The acute toxicity of 2-[2-(3-butoxypropyl)-1,1-dioxo-1,2,4-benzothiadiazin-3yl]-5'-tert-butyl-2-(5,5-dimethyl-2,4-dioxo-
1,3-oxazolidin-3-yl)-2'-[(2-ethylhexyl)thio]acetanilide (UY-330) to algae was determined in a study by Bouwman (2004). This test was conducted according to ISO 6341 15, EU Method C.2 and OECD Guideline 202 following GLP requirements. During the study, two limit tests were performed under static conditions. Algae (Pseudokirchneriella subcapitata, former Selenastrum capricornutum) were exposed for 72 hours to a filtered solution prepared at 100 mg/L nominal (verification of test concentration was performed by HPLC analysis). No mortality or other adverse effects could be observed at the end of the exposure period and therefore, an ErC50 value could not be calculated and it is considered to be > 0.02 mg/L (measured concentration).
In conclusion, UY-330 was not acutely toxic to invertebrates under the tested conditions. No effects of the substance are expected in the range of the water solubility of the test substance (0.04 mg/L). Thus, in addition an ErC50 > 100 mg/L based on the nominal test concentration of the test substance in a filtered solution is assumed and reported in the study summary.
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