Registration Dossier
Registration Dossier
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EC number: 411-080-5 | CAS number: -
Endpoint summary
Administrative data
Description of key information
In a subacute oral toxicity study male and female rats were treated by gavage with Pigment Yellow FC 26290 at doses of 0 (physiol. saline), 40, 200 and 1000 mg/kg bw for 28 consecutive days. Clinical signs, body weight, food consumption, organ weights, clinical biochemistry and hematological parameters were recorded and a gross and histopathological examination was conducted.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Additional information
In the subacute oral toxicity study the appearance and general behaviour was not influenced by treatment up to and including 1000 mg/kg. The general condition was temporarily reduced in some animals of the dose group 1000 mg/kg. Growth, mortality, feed and water intake were not affected by treatment. Hematological and histopathological investigations gave no indication of toxicologically relevant damage to blood or hematopoietic organs up to and including 1000 mg/kg. Neither clinico-chemical nor gross pathological or histopathological investigations produced any evidence of treatment-related metabolic or organ damage.
Under the conditions described the NOAEL for Pigment Yellow FC 26290 is 1000 mg/kg bw/day.
Justification for classification or non-classification
Based on the results of the subacute oral toxicity study a classification is not justified
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