Registration Dossier
Registration Dossier
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EC number: 951-773-4 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- other: Expert statement
- Adequacy of study:
- weight of evidence
- Study period:
- 2020-08-12
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Expert statement based on literature datea and calculations of the single contsituents.
- GLP compliance:
- no
- Type of method:
- calculation method (fragments)
- Partition coefficient type:
- octanol-water
- Analytical method:
- not specified
- Key result
- Type:
- log Pow
- Partition coefficient:
- < -1
- Remarks on result:
- other: Temperature and pH are not available.
- Conclusions:
- Taken together, the partition coefficient is seen to be below -1.0.
- Executive summary:
The test substance ”Guanidinoacetic acid – Mother liquor“ was to be assessed for its partition coefficient. An experimental determination of the partition coefficient following the given methodology is not useful due to the test items composition and the limitation of the recommended method; therefore an estimation based on QSPR calculations and literature was done under consideration of the values given in the literature.
Taken together, the partition coefficient is seen to be below -1.0.
Reference
Description of key information
The Partition coefficient was estimated taking data from ECH, experimental literature data and QSAR-Calculations (Chemicalize and Epi-Suite) into account.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -1
Additional information
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