Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
dissociation constant
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
comparable to guideline study with acceptable restrictions

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2002

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 112 (Dissociation Constants in Water)
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
1-BUTANESULFONAMIDE, 1,1,2,2,3,3,4,4,4-NONAFLUORO-N-METHYL-
EC Number:
614-396-3
Cas Number:
68298-12-4
Molecular formula:
C5H4F9NO2S
IUPAC Name:
1-BUTANESULFONAMIDE, 1,1,2,2,3,3,4,4,4-NONAFLUORO-N-METHYL-

Results and discussion

Dissociating properties:
yes
Dissociation constant
No.:
#1
pKa:
7.52
Remarks on result:
other: Temperature and pH not provided

Applicant's summary and conclusion

Conclusions:
The pKa for MeFBSA was found to be 7.52.
Executive summary:

The pKa was determined for MeFBSA was determined using automated pH titration. The study was performed comparable to a guideline study but was not GLP compliant and was lacking sufficient documentation; therefore the study is considered reliable with restrictions.