Registration Dossier
Registration Dossier
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EC number: 248-230-2 | CAS number: 27115-36-2
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Based on Chromium 3+ ions
- Adequacy of study:
- key study
- Study period:
- Single dose
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- accepted calculation method
- Justification for type of information:
- There is evidence that the biological effects of chromium salts is based on the dissociated chromium ion.
The substance dissociates in water or biological systems
Data source
Reference
- Reference Type:
- publication
- Title:
- Safety and toxicological evaluation of a novel niacin-bound chromium (III) complex
- Author:
- Shara M, Yasmin T, Kincaid AE, et al
- Year:
- 2 005
- Bibliographic source:
- J Inorg Biochem. 2005;99(11):2161–2813.
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- GLP compliance:
- not specified
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Chromium triformate
- EC Number:
- 248-230-2
- EC Name:
- Chromium triformate
- Cas Number:
- 27115-36-2
- Molecular formula:
- Cr(CHO2)3
- IUPAC Name:
- chromium triformate
- Test material form:
- solid: particulate/powder
Constituent 1
- Specific details on test material used for the study:
- Various chromium salts, including nicotinate used for the calculation
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- 24 hours
- Doses:
- 2000 mg/kg
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No
- Clinical signs:
- other: Slight irritation
- Gross pathology:
- Not specified
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- It has been demonstrated that systemic toxicity to chromium 3+ is based on the dissociated ions.
The LD50 of chromium 3+ is considered > 600 mg/kg as Chromium 3+ based on different salts
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