Registration Dossier
Registration Dossier
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EC number: 248-230-2 | CAS number: 27115-36-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Justification for type of information:
- Guideline study to GLP
Confirms irritancy of simple organic acid salts of chromium III
Acetate salt is seen as a suitable surrgoate for formate; the two salts are water soluble and with similar pH
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 492 (Reconstructed Human Cornea-like Epithelium (RhCE) Test Method for Identifying Chemicals Not Requiring Classification and Labelling for Eye Irritation or Serious Eye Damage)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Chromium acetate
- EC Number:
- 241-562-9
- EC Name:
- Chromium acetate
- Cas Number:
- 17593-70-3
- Molecular formula:
- 3Cr, < 3(C2H4O2) < 1(OH)
- IUPAC Name:
- Chromium III hydroxyacetate
Constituent 1
- Specific details on test material used for the study:
- Confirms irritancy of simple organic acid salts of chromium III and that Eye Dam 1 is not needed
Acetate salt is seen as a suitable surrgoate for formate; the two salts are water soluble and with similar pH
Results and discussion
In vitro
Results
- Irritation parameter:
- in vitro irritation score
- Run / experiment:
- 1
- Value:
- ca. 4.4
- Vehicle controls validity:
- valid
- Negative controls validity:
- valid
- Positive controls validity:
- valid
- Other effects / acceptance of results:
- The low viability is close to figures seen for Eye Dam 1.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- It is noted that this method alone cannot validate the division between Eye Dam 1 and Eye Irrit 2 and Eye Dam 1 is assigned as a precautionary approach
The substance is typically supplied in acidic mixtures.
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