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Physical & Chemical properties

Water solubility

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Reference
Endpoint:
water solubility
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2003-09-02 to 2003-09-13
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Reason / purpose for cross-reference:
reference to same study
Qualifier:
according to guideline
Guideline:
OECD Guideline 105 (Water Solubility)
Version / remarks:
1995
Deviations:
no
Qualifier:
according to guideline
Guideline:
EU Method A.6 (Water Solubility)
Version / remarks:
1992
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Remarks:
signed, 2003-03
Type of method:
column elution method
Specific details on test material used for the study:
Appearance: Solid
Storage: At room temperature at about 20 °C
Water solubility:
< 63.6 µg/L
Conc. based on:
test mat. (dissolved fraction)
Loading of aqueous phase:
1.4 g/L
Incubation duration:
86 h
Temp.:
20 °C
pH:
ca. 7.4

Results of the water solubility of the test item

Experiment No.

Flow rate

[mL/h]

Sample No.

Concentration analysed [μg/mL)

Water solubility calculated [mg/L]

pH

 

1

31

1

2

3

4

5

6

< 0.06364

< 0.06364

< 0.06364

< 0.06364

< 0.06364

< 0.06364

< 0.06364

7.41

7.38

7.36

7.39

7.40

7.41

7.39

7.42

7.38

7.37

7.39

7.41

2

16

7

8

9

10

11

12

< 0.06364

< 0.06364

< 0.06364

< 0.06364

< 0.06364

< 0.06364

During the preliminary test the water solubility of the test substance at room temperature was estimated by a simplified flask method to be lower than the smallest calibration point of 0.0636 μg/mL. Therefore the column elution method was used for the performance of the main test.

During the main test six samples have been analysed in the first run (0.52 mL/min) and six samples during the second run (0.26 mL/min), each with a sampling interval of one hour. Total elution time was 86 hours. The sample measurement was performed by HPLC. The measured results differ by less than 30 %. Therefore the study is considered to be valid.

The test item could not be detected in any of the eluate samples.

In conclusion, the water solubility of the test substance at 20 °C was determined to be < 0.0636 mg/L using the column elution method.

Conclusions:
The water solubility of the test item at 20 ° C was determined to be < 0.0636 mg/L using the column elution method.

Description of key information

The water solubility of the test item at 20 °C was determined to be < 63.6 µg/L using the column elution method.

Key value for chemical safety assessment

Additional information