2-ethylhexyl 2-([1,1'-biphenyl]-4-ylcarbonyl)benzoate

pH

Administrative data

Endpoint:

pH

Type of information:

experimental study

Adequacy of study:

key study

Study period:

11 Mar 2020 - 23 Apr 2020

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2020

Report date:

2020

Materials and methods

Test guideline

Test guideline 1

Qualifier:

according to guideline

Guideline:

CIPAC MT 75 (Determination of pH Values)

Version / remarks:

Volume J MT 75.3; 2000

Deviations:

no

Test guideline 2

Qualifier:

according to guideline

Guideline:

OECD Guideline 122 (Determination of pH, Acidity and Alkalinity)

Version / remarks:

26 July 2013

Deviations:

no

Test guideline 3

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7000 (pH)

Version / remarks:

August 1996

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Test material

Test material information

Constituent 1

Reference substance name:

2-ethylhexyl 2-([1,1'-biphenyl]-4-ylcarbonyl)benzoate

EC Number:

278-051-5

EC Name:

2-ethylhexyl 2-([1,1'-biphenyl]-4-ylcarbonyl)benzoate

Cas Number:

75005-95-7

Molecular formula:

C28H30O3

IUPAC Name:

2-ethylhexyl 2-{[1,1'-biphenyl]-4-carbonyl}benzoate

Test material form:

liquid

Details on test material:

Purity/Composition: 96.27%
Storage Conditions: At room temperature
Test Facility test item number: 210244/A
Test item handling: No specific handling conditions required
CAS number: 75005-95-7
EC Number: 278-051-5
Substance Name: 2-ethylhexyl 2-([1,1'-biphenyl]-4-ylcarbonyl)benzoate

Specific details on test material used for the study:

Physical Description: Colourless to pale yellow liquid (determined by Charles River Den Bosch)
Purity/Composition: 96.27%
Storage Conditions: At room temperature
Purity/Composition correction factor: No correction factor required
Test item handling: No specific handling conditions required
Chemical name: 2-Ethylhexyl 2-([1,1'-biphenyl]-4-ylcarbonyl)benzoate
CAS number: 75005-95-7
EC Number: 278-051-5
Molecular formula: C28H30O3
Molecular weight: 414.22

Reagents

Reagent:

other: See below

Titration of acidity and alkalinity

Details on titrant used:

Chemicals and Reagents
Text Table 9
Chemicals and Reagents
Chemical / Reagent Supplier
Double distilled water Waldeck, Münster-Roxel, Germany
Potassium hydrogen phthalate (C8H5KO4) Merck, Darmstadt, Germany
Di-sodium tetraborate decahydrate (Na2B4O7.10H2O) Sigma-Aldrich, Steinheim, Germany
0.05M buffer solution pH 4.00 ± 0.02 5.1056 g potassium hydrogen phthalate dried for 2 hours at 105°C, dissolved in double distilled water and made up to 500 mL
0.05M buffer solution pH 9.22 ± 0.02 9.5353 g di-sodium tetraborate decahydrate dissolved in double distilled water and made up to 500 mL
All chemicals and reagents were of analytical grade, unless specified otherwise.

Performance of the Study
The pH of two 1% (w/v) mixtures of the test item in double distilled water was measured using a 906 Titrando (Metrohm, Herisau, Switzerland) and a combined glass electrode (glass glass electrode and reference electrode, Metrohm).
The pH meter was calibrated using a 0.05 M potassium hydrogen phthalate buffer solution (pH 4.00) and a 0.05 M di-sodium tetraborate buffer solution (pH 9.22 at 20°C). At the start and at the end of the measurements, pH of these buffer solutions was measured to ensure proper performance of the pH meter.
For the preparation of the 1% (w/v) mixtures, accurately weighed amounts of 1.0069 g and 1.0015 g of the test item were transferred into a 100 mL measuring cylinder, containing about 50 mL double distilled water. The volume was made up to 100 mL with water, the cylinder was stoppered and the dispersion was shaken vigorously by hand until completely mixed or dispersed. After it was left to stand for 1 minute, the combined glass electrode was immersed into the liquid and the pH was measured without stirring. The pH value was recorded after 1 and 2 minutes. Because the pH value changed more than 0.1 unit during this equilibration time, the pH was also recorded 10 minutes after immersion of the electrode.
The test was performed at 21.5 ± 0.4°C.

Results and discussion

pH value

pH value:

5.8

Temp.:

21.5 °C

Concentration:

1 other: % w/v

Any other information on results incl. tables

The results of the test on the determination of the pH of the test item are given in Table 8.

The 1% (w/v) mixtures of the test item in double distilled water were white turbid suspensions with drops of test item throughout the measuring cylinder.

The pH of the 1% (w/v) aqueous mixtures was 5.8.

Table 8   pH of the Test Item

	pH
	1% (w/v) mixture
	5.616
	5.962
Mean	5.8

Applicant's summary and conclusion

Conclusions:

the pH of the substance was determined to be 5.8 under the conditions of the test.

Executive summary:

Under GLP conditions, the pH of the substance was determined to be 5.8 under the conditions of the test according to guidelines CIPAC MT 75.3, OECD 122 & OPPTS 830.7000.