Reaction products of 1,4-Benzenedimethanol and 1-naphthol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

06 September 2019 to 11 September 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Reason / purpose for cross-reference:

reference to same study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

GLP compliance:

yes (incl. QA statement)

Type of method:

column elution method

Specific details on test material used for the study:

No further details specified in the study report

Key result

Water solubility:

0.2 other: μg/mL

Conc. based on:

test mat.

Loading of aqueous phase:

50 other: mg/ 50ml

Incubation duration:

2 h

Temp.:

19.6 °C

pH:

>= 6.58 - <= 6.78

Details on results:

pH of the samples varied in the range of 6.58-6.78.
Samples were analysed with the above HPLC method. The samples were not detectable, or were detectable but their areas were significantly lower than area of lowest calibration (LOQ, Limit of Quantification). Control water was measured as well in every case, no peak was detected in control samples. The mean value from (at least five) consecutive samples taken from the saturation (plateau) were calculated for each run. Because the measured concentration was less than the LOQ of the HPLC method after 5 days, the test was terminated.

Measured concentration of test item from micro-columns

Time (day)	Micro- column I (25 mL/h)		Micro- column II (12.5 mL/h)
	Measured concentration μg/L	pH	Measured concentration μg/L	pH
1	< LOQ	6.58	< LOQ	6.70
	< LOQ	6.66	< LOQ	6.78
2	< LOQ	6.61	< LOQ	6.64
	< LOQ	6.68	< LOQ	6.71
3	< LOQ	6.72	< LOQ	6.75
	< LOQ	6.76	< LOQ	6.77
Mean	< LOQ	-	< LOQ	-

 

The measured concentration of the samples was below the quantification limit within the 1-day measurement and after the comparison of the 3-day results (in six consecutive measurements).

The measured pH of the samples also did not show significant difference from each other. The comparative pH of the water suggested that the test item cannot be dissolved in water.

In conclusion, the water solubility of CAS 113601-85-7 was determined to be below the quantification limit after 5 days equilibration time, considering to the dilution rates, the water solubility of test item is less than 0.2 μg/mL at 20°C ± 0.5°C using the column elution method. The test item is considered to be highly insoluble in water.

Conclusions:

The water solubility of test item is less than 0.2 μg/mL at 20°C ± 0.5°C using the column elution method.

Executive summary:

The water solubility of test item CAS 113601 -85 -7 was determined in accordance to OECD test guideline 105, in compliance with GLP.

The water solubility of CAS 113601-85-7 was determined using the column elution method. It was found to be less than 0.2 μg/mL at 20°C ± 0.5°C after 5 days equilibration time. The test item is considered to be highly insoluble in water.

Description of key information

The water solubility of test item is less than 0.2 μg/mL at 20°C ± 0.5°C using the column elution method.

Key value for chemical safety assessment

at the temperature of:

20 °C