Registration Dossier

Data platform availability banner - registered substances factsheets

Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Physical & Chemical properties

Partition coefficient

Currently viewing:

Administrative data

Link to relevant study record(s)

Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
19 June 2019 to 24 June 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to guideline
Guideline:
other: Method A.24.
Version / remarks:
“Partition Coefficient (n-octanol/water), High Performance Liquid Chromatography (HPLC) method”, Official Journal of the European Union L 54 of 01 March 2016
Deviations:
no
GLP compliance:
yes (incl. QA statement)
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Specific details on test material used for the study:
No further details specified in the study report
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
>= 1.64 - <= 6.49
Temp.:
25 °C
Remarks on result:
other: pH value not specified
Details on results:
The three calibration series (reference solutions) and three test item series were measured using the standard conditions. The partition coefficient Pow was determined based on a calibration curve using 8 reference substances.
The capacity factors “k” were calculated from the dead time and retention times of the reference substances. The log k data of the reference substances were plotted against their log Pow values.

The calibration curve met the acceptance criteria between log Pow 1.6 and 6.5.

The estimated log Pow values of the 22 significant visible peaks

Peak Number

Log Pow

Confidential interval (95%)

1

1.64

0.000

2

2.07

0.006

3

2.63

0.003

4

2.89

0.004

5

3.42

0.002

6

3.61

0.002

7

3.77

0.002

8

3.92

0.002

9

4.09

0.000

10

4.25

0.001

11

4.39

0.002

12

4.55

0.001

13

4.67

0.000

14

4.82

0.000

15

5.60

0.001

16

5.73

0.001

17

5.90

0.002

18

6.01

0.001

19

6.06

0.001

20

6.18

0.003

21

6.29

0.001

22

6.49

0.001
Conclusions:
The test item showed 22 significant visible peaks. The estimated log Pow values are varying in range 1.64 – 6.49.
Executive summary:

The partition coefficient of test item CAS 113601 -85 -7 was determined in accordance to OECD test guideline 117, in compliance with GLP.

During the course of this study the partition coefficient (log Pow) of CAS 113601-85-7 was estimated using high performance liquid chromatography.

The test item showed 22 significant visible peaks. The estimated log Pow values are varying in range 1.64 – 6.49.

Description of key information

The test item showed 22 significant visible peaks. The estimated log Pow values are varying in range 1.64 – 6.49.

Key value for chemical safety assessment

Log Kow (Log Pow):
1.64
at the temperature of:
25 °C

Additional information