Registration Dossier

Administrative data

Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
13 Mar - 20 Apr 2019
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
2019
Report Date:
2019

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
not specified
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
not specified
GLP compliance:
yes (incl. certificate)
Remarks:
Landesamt für Umwelt Rheinland-Pfalz; Mainz, Germany
Type of method:
effusion method: by loss of weight or by trapping vaporisate

Test material

Reference
Name:
Unnamed
Type:
Constituent
Test material form:
solid: particulate/powder

Results and discussion

Vapour pressureopen allclose all
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0 Pa
Test no.:
#2
Temp.:
25 °C
Vapour pressure:
0 Pa

Any other information on results incl. tables

Final Results:

The following vapour pressures were determined experimentally and considered as valid (mean and standard deviation given):

T

T

p

Stand.Dev.p

RSD p

°C

K

Pa

Pa

%

120.0

393.2

1.15E-02

1.23E-03

10.7%

135.0

408.2

3.11E-02

8.01E-04

2.6%

150.0

423.2

1.70E-01

3.24E-02

19.1%

For the test item W-1108T, the following vapour pressures at 20°C and at 25°C were calculated from the regression equation:

Vapour pressure at 20°C:

2.43*10 -08 Pa

Vapour pressure at 25°C:

5.71*10 -08 Pa

The linear regression of log p vs. 1/T gave a correlation coefficient r of - 0.9854, showing good repeatability and precision. Therefore, the determination is considered as valid.

Positive Control:

For Diethylphthalate the following vapour pressure was determined and compared with recommended value:

Vapour pressure(positivecontrol) at 30°C:

1.92*10 -1 Pa

Criterion for the vapour pressure of the positive control at 30°C

0.44*10 -1 -2.44*10 -1 Pa

The vapour pressure met the validity criteria. Therefore the study can be considered as valid.

Discussion:

The vapour pressure of the test item W-1108T was determined at nine different temperatures (30, 45, 60, 75, 90, 105, 120, 135 and 150 °C) according to OECD 104 resp. EU A.4 using the effusion method (weight loss). Experiment 1 - 6 (nominal temperature 30 - 105 °C) showed no reproducible weight loss. When visible contaminations, caused by explosive evaporation of the test item, were observed, the cells were meticulously cleaned and weighed. This weight was used as initial weight for the subsequent measurements. To avoid bias, these measurements were not used for calculations.

 

Three experiments could be evaluated as they showed relevant and reproducible weight loss. All evaluated experiments showed good repeatability, giving relative standard deviations of less than 20 % (limit value from the guideline 30 %) and good correlation. Therefore, the result of the test can be considered valid.

Applicant's summary and conclusion