Registration Dossier
Registration Dossier
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EC number: 821-932-1 | CAS number: 694510-10-6
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- May 17, 2018 - May 18, 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- other: A.24. Partition coefficient n-octanol/water
- Version / remarks:
- European Commission Regulation (EC) No. 440/2008 and No. 2016/266
- Deviations:
- no
- GLP compliance:
- no
- Type of method:
- HPLC method
- Partition coefficient type:
- octanol-water
- Analytical method:
- high-performance liquid chromatography
- Key result
- Type:
- log Pow
- Partition coefficient:
- > 6.5
- Temp.:
- 25 °C
- Remarks on result:
- other: pH not determined
- Conclusions:
- The log partition coefficient n-octanol/water was determined by using the HPLC method and was found to be greater than 6.5.
- Executive summary:
The partition coefficient n-octanol/water of the test item was determined according to OECD Guideline 117 and EU Method A.24. Based on the preliminary result obtained from EPI Suite, the log Pow value was determined by using the HPLC Method. The log Pow of the test item was found to be greater than 6.5 and is thus above the highest log Pow value of calibration substances (4,4'-DDT).
Reference
Preliminary test
The calculated value was 8.94. Therefore, the partition coefficient n-octanol/water of the test item at room temperature was determined by HPLC method.
Main test
The results showed a significant deviation from the calculated value by Episuite. Additionally, it was difficult to find suitable conditions for the detection of the test item. Therefore, only >6.5 was given as final result for the partition coefficient n-octanol/water which is above the highest log Pow value of calibration substances (4,4'-DDT).
Description of key information
The log Pow of the test item was found to be greater than 6.5.
Key value for chemical safety assessment
Additional information
The partition coefficient n-octanol/water of the test item was determined according to OECD Guideline 117 and EU Method A.24 (reference 4.7 -1). Based on the preliminary result obtained from EPI Suite, the log Pow value was determined by using the HPLC Method. The log Pow of the test item was found to be greater than 6.5 and is thus above the highest log Pow value of calibration substances (4,4'-DDT).
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