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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
May 17, 2018 - May 18, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 117 (Partition Coefficient (n-octanol / water), HPLC Method)
Deviations:
no
Qualifier:
according to
Guideline:
other: A.24. Partition coefficient n-octanol/water
Version / remarks:
European Commission Regulation (EC) No. 440/2008 and No. 2016/266
Deviations:
no
GLP compliance:
no
Type of method:
HPLC method
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
> 6.5
Temp.:
25 °C
Remarks on result:
other: pH not determined

Preliminary test

The calculated value was 8.94. Therefore, the partition coefficient n-octanol/water of the test item at room temperature was determined by HPLC method.

Main test

The results showed a significant deviation from the calculated value by Episuite. Additionally, it was difficult to find suitable conditions for the detection of the test item. Therefore, only >6.5 was given as final result for the partition coefficient n-octanol/water which is above the highest log Pow value of calibration substances (4,4'-DDT).

Conclusions:
The log partition coefficient n-octanol/water was determined by using the HPLC method and was found to be greater than 6.5.
Executive summary:

The partition coefficient n-octanol/water of the test item was determined according to OECD Guideline 117 and EU Method A.24. Based on the preliminary result obtained from EPI Suite, the log Pow value was determined by using the HPLC Method. The log Pow of the test item was found to be greater than 6.5 and is thus above the highest log Pow value of calibration substances (4,4'-DDT).

Description of key information

The log Pow of the test item was found to be greater than 6.5.

Key value for chemical safety assessment

Additional information

The partition coefficient n-octanol/water of the test item was determined according to OECD Guideline 117 and EU Method A.24 (reference 4.7 -1). Based on the preliminary result obtained from EPI Suite, the log Pow value was determined by using the HPLC Method. The log Pow of the test item was found to be greater than 6.5 and is thus above the highest log Pow value of calibration substances (4,4'-DDT).