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Vapour pressure

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Reference
Endpoint:
vapour pressure
Type of information:
experimental study
Adequacy of study:
key study
Study period:
April 12, 2018 - April 13, 2018
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to
Guideline:
OECD Guideline 104 (Vapour Pressure Curve)
Deviations:
no
Qualifier:
according to
Guideline:
EU Method A.4 (Vapour Pressure)
Deviations:
no
GLP compliance:
no
Type of method:
effusion method: Knudsen cell
Test no.:
#1
Temp.:
20 °C
Vapour pressure:
0.002 Pa
Key result
Test no.:
#1
Temp.:
25 °C
Vapour pressure:
0.004 Pa
Test no.:
#1
Temp.:
50 °C
Vapour pressure:
0.076 Pa

The vapour pressure was measured in the temperature range of 20 °C to 100 °C (no measurements between 55 °C and 95 °C to exclude an influence from the melting point). Above 100 °C no further measurements were possible as the test item had completely evaporated at 100 °C. The measured vapour pressures at the corresponding temperatures are listed in Table 1. After the measurement a mass loss of approx. 100 % (w/w) was determined.

Table 1: Measured vapour pressures and corresponding temperatures

 Temperature in °C  Vapour pressure in hPa
20 3E-5
30 6.6E-5
40 2.3E-4
 50 7.7E-4
100 8.6E-2

Table 2: Antoine parameters and extrapolated vapour pressures

 T/°C  p / hPa  

log (p/hPa) = A +B/(C+T[°C])

20 2.2E-5 A = 11.87988
25 4.2E-5  B = -4846.90
50 7.6E-4 C= 273.15

Table 3: Final Results

 T/°C  p / hPa  p / Pa
20

2.2E-5

2.2E-3

25

4.2E-5

4.2E-3

 50

 7.6E-4

7.6E-2

Conclusions:
The vapour pressure of the test item was determined to be 2.2E-3 Pa at 20 °C, 4.2E-3 Pa at 25 °C and 7.6E-2 Pa at 50 °C, respectively.
Executive summary:

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance. The vapour pressure was measured in the temperature range of 20 °C to 100 °C (no measurements between 55 °C and 95 °C to exclude an influence from the melting point). Above 100 °C no further measurements were possible as the test item had completely evaporated at 100 °C. Using the Antoine equation, the constants A, B and C were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure of the test item was determined to be 2.2E-3 Pa at 20 °C, 4.2E-3 Pa at 25 °C and 7.6E-2 Pa at 50 °C, respectively.

Description of key information

The vapour pressure of the test item was determined to be 2.2E-3 Pa at 20 °C, 4.2E-3 Pa at 25 °C and 7.6E-2 Pa at 50 °C, respectively.

Key value for chemical safety assessment

Vapour pressure:
0.004 Pa
at the temperature of:
25 °C

Additional information

A study was conducted according to OECD TG 104 and Regulation (EC) No 440/2008 method A.4 to determine the vapour pressure of the test item using the effusion method: vapour pressure balance (reference 4.6 -1).The vapour pressure was measured in the temperature range of 20 °C to 100 °C (no measurements between 55 °C and 95 °C to exclude an influence from the melting point). Above 100 °C no further measurements were possible as the test item had completely evaporated at 100 °C. Using the Antoine equation, the constants A, B and C were determined and the vapour pressure of the test item at 20, 25 and 50 °C was extrapolated from the experimental vapour pressure. The vapour pressure of the test item was determined to be 2.2E-3 Pa at 20 °C, 4.2E-3 Pa at 25 °C and 7.6E-2 Pa at 50 °C, respectively.