4-methyloxazole-5-carbonitrile

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

10/ 2000 - 02/ 2001

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: study performed according to GLP and OECD guidelines

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

2001

Report date:

2001

Materials and methods

Test guideline

Qualifier:

according to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

no

Principles of method if other than guideline:

-

GLP compliance:

yes (incl. QA statement)

Test type:

acute toxic class method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

4-methyloxazole-5-carbonitrile

EC Number:

213-709-7

EC Name:

4-methyloxazole-5-carbonitrile

Cas Number:

1003-52-7

Molecular formula:

C5H4N2O

IUPAC Name:

4-methyl-1,3-oxazole-5-carbonitrile

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

unchanged (no vehicle)

Doses:

2000, 930, 430, 200 mg/kg BW

No. of animals per sex per dose:

5 per sex per dose

Control animals:

no

Results and discussion

Effect levels

Effect levels 1

Sex:

male

Dose descriptor:

LD50

Effect level:

735 mg/kg bw

95% CL:

>= 452 - <= 1 199

Effect levels 2

Sex:

female

Dose descriptor:

LD50

Effect level:

632 mL/kg bw

95% CL:

>= 267 - <= 1 500

Any other information on results incl. tables

no additional remarks

Applicant's summary and conclusion

Interpretation of results:

harmful

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The LD50 value of Cyanomethyloxazol was determined to 735.87 mg/kg for male rats and to 632.46 mg/kg for female rats according to the Moving Averages Computation.

Executive summary:

The test substance was administered orally in a single dose to four groups of Sprague Dawley rats: Group I (l0 rats, 5 males and 5 females) 2000 mg/kg applied; Group II (l0 rats, 5 males and 5 females) 930 mg/kg applied Group III (10 rats, 5 males and 5 females) 430 mg/kg applied Group IV (10 rats, 5 males and 5 females) 200 mg/kg applied. Mortality attributed to the exposure to Cyanomethyloxazol could be observed in 10 rats dosed with 2000 mg/kg, in 8 rats dosed with 930 mg/kg, in 1 rat dosed with 430 mg/kg and in 0 rats dosed with 200 mg/kg. The post-mortem findings did not show any macroscopic organ changes. The LD50 value of Cyanomethyloxazol was determined to 735.87 mg/kg for male rats and to 632.46 mg/kg for female rats according to the Moving Averages Computation.