Registration Dossier
Registration Dossier
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EC number: 213-709-7 | CAS number: 1003-52-7
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 26 March 2010 - 05 July 2010
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: This study has been performed according to OECD and EC guidelines and according to GLP principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 010
- Report date:
- 2010
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
Test material
- Reference substance name:
- 4-methyloxazole-5-carbonitrile
- EC Number:
- 213-709-7
- EC Name:
- 4-methyloxazole-5-carbonitrile
- Cas Number:
- 1003-52-7
- Molecular formula:
- C5H4N2O
- IUPAC Name:
- 4-methyl-1,3-oxazole-5-carbonitrile
- Details on test material:
- Name of test material (as cited in study report): CMO
Molecular formula: C5H4N2O
Molecular weight: 108.1
Substance type: Clear colourless liquid
Physical state: liquid
Analytical purity: 99.9%
Impurities (identity and concentrations): -
Composition of test material, percentage of components: -
Isomers composition: -
Purity test date: -
Lot/batch No.: 485
Expiration date of the lot/batch: 04 December 2010
Stability under storage conditions: stable
Storage condition of test material: In refrigerator (2-8°C) in the dark under nitrogen
Other: Hygroscopic
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 51.2 g/L
- Temp.:
- 20 °C
- pH:
- 5.6
Any other information on results incl. tables
Main study - water solubility of the test substance
Stirring time |
Analysed concentration |
Mean |
MD |
pH |
|
|
|
|
|
24 |
50.6 |
51.2 |
3.1 |
6.6 |
|
|
|
|
|
48 |
51.0 |
|
|
6.3 |
|
|
|
|
|
72 |
52.1 |
|
|
5.6 |
|
|
|
|
|
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): very soluble (> 10000 mg/L)
The flask method was chosen for the determination of the water solubility of CMO.
The water solubility of the test substance at 20°C was 51.2 g/l. The pH of the aqueous sample after 72 hours stirring was 5.6.
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