Registration Dossier
Registration Dossier
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EC number: 234-207-4 | CAS number: 10595-80-9
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1957
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 957
- Report date:
- 1957
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- 4 rabbits were exposed to the undiluted test substance in the abdominal region.
- GLP compliance:
- no
- Remarks:
- GLP regulations were not in place at the time of this study
Test material
- Reference substance name:
- Sulphoethyl methacrylate
- EC Number:
- 234-207-4
- EC Name:
- Sulphoethyl methacrylate
- Cas Number:
- 10595-80-9
- Molecular formula:
- C6H10O5S
- IUPAC Name:
- sulphoethyl methacrylate
- Test material form:
- liquid: viscous
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Test system
- Type of coverage:
- not specified
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- not required
- Amount / concentration applied:
- undiluted and 10% aqueous solution, amount not specified
- Duration of treatment / exposure:
- 1 to 5 min
- Observation period:
- up to 21 days
- Number of animals:
- 4 undiluted
3 diluted - Details on study design:
- not specified
Results and discussion
In vivo
Results
- Irritation parameter:
- other: corrosion
- Basis:
- mean
- Time point:
- other: 5 min
- Remarks on result:
- probability of severe irritation
- Remarks:
- corrosion
- Irritant / corrosive response data:
- 1 min exposure: slight hyperaemia
3 min exposure: slight hyperaemia with moderate necrosis
5 min exposure: extensive necrosis resulting in heavy scab - Other effects:
- One animal (exposure duration not reported) was sacrificed because of extensive skin damage.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1B (corrosive) based on GHS criteria
- Conclusions:
- Exposure to undiluted 2-SEM for 5 minutes caused skin corrosion, whereas exposure for 3 minutes caused skin irritation.
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