Registration Dossier
Registration Dossier
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EC number: 500-013-6 | CAS number: 9004-78-8 1 - 2.5 moles ethoxylated
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- other: expert assessment
- Adequacy of study:
- key study
- Study period:
- 2019
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Assessment based on the properties of the indvidiual constituents of the substance
Data source
Reference
- Reference Type:
- other: expert assessment
- Title:
- Unnamed
- Year:
- 2 019
- Report date:
- 2019
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Principles of method if other than guideline:
- An assessment was conducted based on the properties of the indvidiual constituents of the substance.
- GLP compliance:
- no
- Test type:
- other: Assessment based on the properties of the indvidiual constituents of the substance
- Limit test:
- no
Test material
- Reference substance name:
- Phenol, ethoxylated
- EC Number:
- 500-013-6
- EC Name:
- Phenol, ethoxylated
- Cas Number:
- 9004-78-8
- Molecular formula:
- not applicable - the substance is a multiconstituent substance
- IUPAC Name:
- 2-phenoxyethan-1-ol
- Test material form:
- liquid
Constituent 1
Results and discussion
Effect levels
- Remarks on result:
- other: An assessment was conducted based on the properties of the indvidiual constituents of the substance. It concluded that Phenol, ethoxylated should be classified as Acute Tox 4; H302.
Applicant's summary and conclusion
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- An assessment was conducted based on the properties of the indvidiual constituents of the substance. It concluded that Phenol, ethoxylated should be classified as Acute Tox 4; H302.
- Executive summary:
The Acute Oral Toxicity of Phenol, ethoxylated was assessed based on the available information on its constituents.
2-phenoxyethanol is associated to a Harmonised Classification as Acute Tox 4; H302, which was confirmed during the REACH Registration of the substance.
2-(2-phenoxyethoxy)ethanol was concluded not to meet the criteria for classification for this endpoint based on available experimental data on the substance.
Considering the structural similarities between the constituents of Phenol, ethoxylated, and in the absence of experimental data on the substance, 2-[2-(2-phenoxyethoxy)ethoxy]ethanol is not expected to be toxic following an acute exposure via the oral route.
While it can be concluded according to the CLP Regulation that Phenol, ethoxylated does not meet the criteria for classification as toxic following an acute oral exposure, it is suggested to classify the substance as Acute Tox 4; H302 to compensate the lack of information on one of the constituents of the substance.
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