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EC number: 214-379-7 | CAS number: 1123-85-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- September 1974
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The studies were performed in 1974, prior to availability of OECD guidelines and EU-testing methods, but however do follow scientific principles.
Oral toxicity was tested at six different dose levels with 10 rats each, whereas deraml toxicity was only tested at one dose level (5 g/kg bw) as this value already was lower than the LD50 (1 out of 5 animals died). Symptom observed were recorded and reported. - GLP compliance:
- no
- Remarks:
- pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- 2-phenylpropan-1-ol
- EC Number:
- 214-379-7
- EC Name:
- 2-phenylpropan-1-ol
- Cas Number:
- 1123-85-9
- Molecular formula:
- C9H12O
- IUPAC Name:
- 2-phenylpropan-1-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Six doses (5, 3, 2.5, 2, 1 and 0.5 g/kg bw) were applied to 10 animals per dose group.
- No. of animals per sex per dose:
- 10 animals per dose group (5m & 5f)
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 2 300 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- >= 1 893 - <= 2 707
- Mortality:
- At 5 g/kg bw all animals died (8 on day 1, 1 on day 2 and 1 on day 4)
At 3 g/kg bw eight animals died on day 1, but none thereafter
At 2.5 g/kg bw five animals died on day 1, but none thereafter
At 2 g/kg bw 3 animals died on day 1 and none thereafter
At 1 g/kg one animal died on day 1 and none thereafter
At 0.5 g/kg bw none of the animals died - Clinical signs:
- other: Ataxia, depression, loss of righting reflex, increased respiration, tremors and twitches were observed symptoms.
- Gross pathology:
- no data
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Remarks:
- not applicable to CLP
- Conclusions:
- The LD50 determined was 2.3 ±0.407 g/kg bw.
- Executive summary:
The substance was assessed for acute oral toxicity to rats, by applying six different doeses (0.5, 1, 2, 2.5, 3 and 5 g/kg bw) to groups of 10 rats each (males and females). Mortality was observed at all dose groups except of 0.5 g/kg bw. The LD50 determined was 2.3 ±0.407 g/kg bw. Symptoms observed were ataxia, depression, loss of righting reflex, increased respiration, tremors and twitches.
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