4-(cyclohexylamino)butane-1-sulfonic acid

Vapour pressure

Link to relevant study record(s)

Reference

Endpoint:

vapour pressure

Type of information:

experimental study

Adequacy of study:

key study

Study period:

15 April 2019 - 08 May 2019

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.4 (Vapour Pressure)

Version / remarks:

2016

Deviations:

no

Qualifier:

according to guideline

Guideline:

OECD Guideline 104 (Vapour Pressure Curve)

Version / remarks:

2006

Deviations:

no

Qualifier:

according to guideline

Guideline:

EPA OPPTS 830.7950 (Vapor Pressure)

Version / remarks:

1996

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Type of method:

effusion method: isothermal thermogravimetry

Specific details on test material used for the study:

Decomposition: 325°C

Key result

Temp.:

20 °C

Vapour pressure:

< 0 Pa

Key result

Temp.:

25 °C

Vapour pressure:

< 0 Pa

Table: Results of the vapour pressure isothermal TGA analysis (substance)

Temperature [°C]	Weight loss [µg/min]	νT [g/cm^2/h]	logνT	logPT	PT [Pa]
200	0.0398964	4.76E^-6	- 5.32	-1.68	2.1E^-2
	0.113795	1.36E^-5	-4.87	-1.10	7.9E^-2
210	0.0442721	5.28E^-6	-5.28	-1.62	2.4E^-2
	0.0986594	1.18E^-5	-4.93	-1.18	6.6E^-2
220	0.0342197	4.08E^-6	-5.39	-1.76	1.7E^-2
	0.0832025	9.93E^-6	-5.00	-1.27	5.3E^-2
230	0.0861876	1.03E^-5	-4.99	-1.25	5.6E^-2
	-0.102807	-1.23E^-5	a	a	a

(a)could not be calculated due to weight increase

The log PT versus 1/T curve for the substance over the range 200 - 230°C showed poor linearity (correlation coefficient r < 0.99). Extrapolation of the curve to 20°C or 25°C would not give reliable results for the vapour pressure of the substance at these temperatures.Since the weight loss of the test item at 200°C, 210°C, 220°C and 230°C was lower than the weight loss of reference substance benzo(ghi)perylene at the same temperatures, it was considered that vapour pressure of the substance at 20°C (25°C) is lower than the vapour pressure of benzo(ghi)perylene at 20°C (25°C).

Conclusions:

The vapour pressure of the substance at 20°C and 25°C was determined to be < 1.3E-8 Pa and < 5.5E-8 Pa, respectively

Executive summary:

The vapour pressure of the substance was determined using the isothermal thermogravimetric effusion method in a GLP study based on EC A.4, OECD 104 and OPPTS 830.7950. Validation of the method was performed using a set of five reference substances. The log PT versus 1/T curve for the substance over the range 200 - 230°C showed poor linearity (correlation coefficient r < 0.99). Extrapolation of the curve to 20°C or 25°C would not give reliable results for the vapour pressure of the substance at these temperatures.

From the measured weight losses in the temperature range 200 - 230°C, the vapour pressure of the substance was determined to be lower than the vapour pressure of reference substance benzo(ghi)perylene. The vapour pressure of the substance at 20°C and 25°C was concluded to be < 1.3E-8 Pa and < 5.5E-8 Pa, resp.

 

Description of key information

Vapour pressure at 25°C: <5.5E-8 Pa (EC A.4, OECD 104, OPPTS 830.7950: isothermal thermogravimetric effusion method)

Key value for chemical safety assessment

Vapour pressure:

0 Pa

at the temperature of:

25 °C

Additional information

Validation of the method was performed using a set of five reference substances.The log PT versus 1/T curve for the substance over the range 200 - 230°C showed poor linearity (correlation coefficient r < 0.99). Extrapolation of the curve to 20°C or 25°C would not give reliable results for the vapour pressure of the substance at these temperatures.

From the measured weight losses in the temperature range 200 - 230°C, the vapour pressure of the substance was determined to be lower than the vapour pressure of reference substancebenzo(ghi)perylene. The vapour pressure of the substance at 20°C and 25°C was concluded to be < 1.3E-8 Pa and < 5.5E-8 Pa, resp.