Registration Dossier
Registration Dossier
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EC number: 206-077-9 | CAS number: 299-35-4
Biodegradation in water: screening tests
Administrative data
- Endpoint:
- biodegradation in water: ready biodegradability
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study according to GLP and OECD guidline
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 001
- Report date:
- 2001
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 301 E (Ready biodegradability: Modified OECD Screening Test)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- 3-(4-amino-2-methylpyrimidin-5-ylmethyl)-5-(2-hydroxyethyl)-4-methylthiazole-2(3H)-thione
- EC Number:
- 206-077-9
- EC Name:
- 3-(4-amino-2-methylpyrimidin-5-ylmethyl)-5-(2-hydroxyethyl)-4-methylthiazole-2(3H)-thione
- Cas Number:
- 299-35-4
- Molecular formula:
- C12H16N4OS2
- IUPAC Name:
- 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-hydroxyethyl)-4-methyl-2,3-dihydro-1,3-thiazole-2-thione
Constituent 1
Study design
- Oxygen conditions:
- aerobic
- Inoculum or test system:
- sewage, domestic, non-adapted
- Details on inoculum:
- - Source of inoculum/activated sludge Zentralklarwerks der Stadtentsorgung
Neustadt (ESN), Im Altenschemel, NW-Lachen-Speyerdorf, lot 19022001
- Storage conditions: aerobic
- Storage length: 2 days
- Pretreatment: 1 hour sedimentation
- Water filtered: no - Duration of test (contact time):
- 28 d
Initial test substance concentration
- Initial conc.:
- 39.8 mg/L
- Based on:
- DOC
Parameter followed for biodegradation estimation
- Parameter followed for biodegradation estimation:
- DOC removal
- Details on study design:
- TEST CONDITIONS
- Test temperature: 21 +- 2°C
- CEC (meq/100 g):
- Continuous darkness: yes/no
- Other:
TEST SYSTEM
- Culturing apparatus: narrow mouth bottle
- Measuring equipment: TOC 5050-A der Fa. Shimadzu
- Test performed in closed vessels due to significant volatility of test substance: no
- Test performed in open system: yes
CONTROL AND BLANK SYSTEM
- Abiotic sterile control: 10 ml 1% HgCl2
- Toxicity control: Test substance + aniline
Reference substance
- Reference substance:
- aniline
Results and discussion
- Preliminary study:
- not performed
- Test performance:
- criteria for test validation fulfilled
% Degradation
- Parameter:
- % degradation (DOC removal)
- Value:
- 0
- Sampling time:
- 28 d
- Details on results:
- no biodegradation observed
BOD5 / COD results
- Results with reference substance:
- biodegradation 95% after 5 days
Any other information on results incl. tables
no overall remarks
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Interpretation of results:
- under test conditions no biodegradation observed
- Conclusions:
- under test conditions no biodegradation observed
- Executive summary:
Thiothiamin was not readily biodegradable under the conditions of the OECD test 301E.
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